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Results for "

lamin A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (2) DNA/RNA Synthesis (2) Ribosomal S6 Kinase (RSK) (1)
By Research Areas:	Cardiovascular Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-159834

Progerinin SLC-D011	DNA/RNA Synthesis	Others
Progerinin (SLC-D011) is an orally active *progerin-lamin* A binding inhibitor. Progerinin selectively binds to the C-terminal region of progerin*, disrupting its interaction with lamin* A and promoting progerin degradation while sparing wild-type lamin A, B, and C. Progerinin ameliorates nuclear deformation, increases H3K9me3 levels, and reduces progerin expression in HGPS patient-derived fibroblasts. Progerinin extends lifespan in Lmna ^G609G/G609G mice and Lmna ^G609G/+ mice, improves body weight, hair morphology, cardiac function, and histological phenotypes. Progerinin can be used for the study of Hutchinson-Gilford progeria syndrome (HGPS) .

HY-115533

LBL1	DNA/RNA Synthesis	Others
LBL1 is a ligand for lamins (especially lamin A, LA) in the nucleus, that stabilizes the oligomeric state of LA, and affects the assembly state of LA. LBL1 can be used to study the assembly state and dynamic changes of LA .

HY-P3054

S6 peptide	Ribosomal S6 Kinase (RSK)	Cardiovascular Disease
S6 peptide is a potentially important lamin kinase. S6 peptide is involved in the process of cardiac hypertrophy induced by mechanical loading. S6 peptide can be activated by many kinds of growth factors .

HY-P2610

Ac-VEID-pNA	Caspase	Others
Ac-VEID-pNA is an artificially synthesized peptide. Ac-VEID-pNA is utilized as substrate for caspase 6, that cleaves the lamin A at the cleavage site of VEID .

HY-W635511

Caspase-6-IN-1	Caspase	Neurological Disease
Caspase-6-IN-1 is a Caspase-6 inhibitor with an IC₅₀ of 5.6 μM. Caspase-6-IN-1 can inhibit Caspase-6 activity and reduce lamin A hydrolysis. Caspase-6-IN-1 can be used for the research of neurodegenerative diseases such as Huntington's disease and Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area

HY-P3054

S6 peptide	Ribosomal S6 Kinase (RSK)	Cardiovascular Disease
S6 peptide is a potentially important lamin kinase. S6 peptide is involved in the process of cardiac hypertrophy induced by mechanical loading. S6 peptide can be activated by many kinds of growth factors .

HY-P2610

Ac-VEID-pNA	Caspase	Others
Ac-VEID-pNA is an artificially synthesized peptide. Ac-VEID-pNA is utilized as substrate for caspase 6, that cleaves the lamin A at the cleavage site of VEID .

Host:	Mouse (4) Rabbit (3)
Reactivity:	Human (7) Rat (7) Mouse (7) Monkey (1)
Application:	IHC-P (6) ICC/IF (3) IF-Tissue (1) IP (1) IHC-F (1) WB (7) FC (1) ELISA (4)
Isotype:	IgG1, k (1) IgG (3) IgG1 (3)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (4) Monoclonal Antibody (1) Recombinant (1)
Modification:	Phosphorylated (1) Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86358

	Lamin A/C Antibody (YA6050) Prelamin-A/C [Cleaved into: lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lamin A/C Antibody (YA6050) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lamin A/C.

HY-P86062

	*Phospho-Lamin* A/C(Ser392) Antibody (YA5754)** Prelamin-A/C [Cleaved into: lamin-A/C; 70 kDa lamin; Renal carcinoma antigen NY-REN-32; ]	WB, ICC/IF, ELISA	Human, Mouse, Rat, Monkey
	Phospho-Lamin A/C(Ser392) Antibody (YA5754) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Phospho-Lamin A/C(Ser392).

HY-P80204

	Lamin A/C Antibody (YA314)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Lamin A/C Antibody is a non-conjugated and Rabbit origined IgG monoclonal antibody, targeting to Lamin A/C. It can be used as a loading control antibody.

HY-P85253

	Lamin A Antibody (YA4945) LMNA; LMN1; Prelamin-A/C	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat
	Lamin A Antibody (YA4945) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Lamin A.

HY-P810665

	*Phospho-Lamin* A + Lamin C (Ser22) Antibody (YA9925)** FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1	WB, IHC-P	Human, Mouse, Rat
	Phospho-Lamin A + Lamin C (Ser22) Antibody (YA9925) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-Lamin A + Lamin C (Ser22).

HY-P83922

	Lamin A Antibody (YA3619) FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1	WB, IHC-P, ELISA	Human, Mouse, Rat
	Lamin A Antibody (YA3619) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lamin A.

HY-P83922A

	Lamin A Antibody (YA3619)(PBS only) FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1	WB, IHC-P, ELISA	Human, Mouse, Rat
	Lamin A Antibody (YA3619) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lamin A.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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