1605301-58-3
Chemical Structure
LBL1
- CAS. Nr.: 1605301-58-3
- Formula:C21H15N5O
- Molecular Weight:353.38
IUPAC Name: N-(1-amino-7H-pyrrolo[3,2-f]quinazolin-3-yl)-2-naphthamide
InChIKey: VRVKVEMREBTSJC-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C=CC=CC2=C1)NC3=NC(N)=C4C5=C(NC=C5)C=CC4=N3
Biological Activity: LBL1 is a Lamin A inhibitor with a Kd of 5.11 μM for LA (1-387). LBL1 directly binds to Lamin A and disrupts the Lamin A-Rad51 interaction, accelerates proteasome-mediated Rad51 degradation, and induces DNA double-strand breaks. LBL1 induces Apoptosis. LBL1 serves as a chemical tool for studying lamin biology and the post-translational regulation of Rad51. LBL1 can be used in studies related to breast cancer and non-small cell lung cancer[1][2][3].
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LBL1 | LBL1 is a Lamin A inhibitor with a Kd of 5.11 μM for LA (1-387). LBL1 directly binds to Lamin A and disrupts the Lamin A-Rad51 interaction, accelerates proteasome-mediated Rad51 degradation, and induces DNA double-strand breaks. LBL1 induces Apoptosis. LBL1 serves as a chemical tool for studying lamin biology and the post-translational regulation of Rad51. LBL1 can be used in studies related to breast cancer and non-small cell lung cancer. | |||||||||||||||||||||
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References
- [1]. Li BX, et al. A Lamin-Binding Ligand Inhibits Homologous Recombination Repair of DNA Double-Strand Breaks. ACS central science. 2018 Sep 26;4(9):1201-1210. [Content Brief]
- [2]. Wang J, et al. CG-SLENP: A Chemical Genetics Strategy To Selectively Label Existing Proteins and Newly Synthesized Proteins. JACS Au. 2024 Jul 25;4(8):3146-3156. [Content Brief]
- [3]. Li BX, et al. Anticancer Pyrroloquinazoline LBL1 Targets Nuclear Lamins. ACS chemical biology. 2018 May 18;13(5):1380-1387. [Content Brief]
