1 Result for "

mutCALRdel52

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "mutCALRdel52" in MCE Product Catalog:

Cat. No.: HY-P991888

Target:  

STAT

Research Areas:  

Cardiovascular Disease Cancer

INCA033989 is a fully human IgG1 monoclonal antibody targeting mutCALR (KD = 1.75 nM for mutCALR del52; KD = 6.78 nM for mutCALR ins5). INCA033989 antagonizes mutCALR-driven signaling and proliferation. INCA033989 selectively inhibits pSTAT3/pSTAT5. INCA033989 prevents thrombocytosis and reduces the expansion of mutCALR-positive cells. INCA033989 is useful for research on myeloproliferative neoplasms .
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