5 Results for "

non-cholinergic

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "non-cholinergic" in MCE Product Catalog:

6
(-)-Huperzine A
(-)-Huperzine A
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6 Cited Publications
Cat. No.: HY-17387
CAS No.: 102518-79-6
Synonyms: Huperzine A
Category:  

Alkaloids Neurological Disease Anti-aging Huperziaceae Terpenoids Sesquiterpenes Pyridine Alkaloids Huperzia serrata (Thunb. ex Murray) Trevis. Plants Disease Research Fields

Target:  

Cholinesterase (ChE) iGluR

(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .
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Ro 22-9194
Ro 22-9194
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Cat. No.: HY-114846
CAS No.: 106134-33-2
Target:  

Prostaglandin Receptor

Research Areas:  

Cardiovascular Disease

Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action .
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(-)-Huperzine A-d4 hydrochloride
(-)-Huperzine A-d4 hydrochloride
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Cat. No.: HY-17387S1
Synonyms: Huperzine A-d4
(-)-Huperzine A-d4 hydrochloride is deuterated labeled (-)-Huperzine A (HY-17387). (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease .
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Tabernanthine
Tabernanthine
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Cat. No.: HY-N8421
CAS No.: 83-94-3
Category:  

Apocynaceae Alkaloids Plants Indole Alkaloids Tabernanthe iboga Baill.

Target:  

Potassium Channel

Tabernanthine is a negative chronotropic and negative inotropic agent that selectively acts on sinoatrial node receptors, regulating heart rhythm and myocardial contractility. Tabernanthine exhibits atropine resistance and direct non-cholinergic binding properties, acting directly on the sinoatrial node rather than relying on vagal nerve or cholinergic pathways to exert its key activity of slowing heart rate and weakening myocardial contractility. Tabernanthine is useful in cardiovascular pharmacology research, particularly in the areas of sinoatrial node function regulation, mechanisms related to bradycardia, and studies of cardiac receptor subtype differences .
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Prepro VIP (111-122), human
Prepro VIP (111-122), human
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Cat. No.: HY-P1761
CAS No.: 123025-94-5
Target:  

Peptides

Research Areas:  

Neurological Disease

Prepro VIP (111-122), human is a prepro-vasoactive intestinal polypeptide (VIP)-derived peptide, corresponding to residues 111-122. VIP is present in the peripheral and the central nervous systems where it functions as a nonadrenergic, noncholinergic neurotransmitter or neuromodulator .
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