2 Results for "

rat αv integrin

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "rat αv integrin" in MCE Product Catalog:

Cat. No.: HY-P99296
CAS No.: 725735-28-4
Synonyms: CNTO 95; Anti-Human CD51 Recombinant Antibody

Target:  

Integrin Apoptosis

Research Areas:  

Cancer

Intetumumab (CNTO 95) is a human monoclonal antibody targeting αv integrin, with a Kd value of 1-24 nM. Through high-affinity binding to αv integrin, Intetumumab inhibits its interaction with extracellular matrix proteins (such as vitronectin and fibronectin), thereby blocking the downstream focal adhesion kinase signaling pathway. This further inhibits the adhesion, migration and invasion of tumor cells as well as the proliferation of vascular endothelial cells, promotes cell apoptosis, and exerts anti-tumor and anti-angiogenic effects. Intetumumab can be used in research related to head and neck cancer, non-small cell lung cancer and uterine serous papillary carcinoma .
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Cat. No.: HY-P10320
Synonyms: Tumstatin (69-88), human
Target:  

PI3K Akt

Research Areas:  

Cardiovascular Disease

T3 Peptide is an active fragment of tumstatin. T3 Peptide binds integrin αvβ3vβ5, activates the PI3K/Akt/p70S6K signaling pathway, and thus stimulates the proliferation and migration of rat cardiac fibroblasts .
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