3 Results for "

total clearance

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "total clearance" in MCE Product Catalog:

Cat. No.: HY-P9995
CAS No.: 2517973-04-3
Synonyms: JNJ-63733657

Target:  

Tau Protein

Research Areas:  

Neurological Disease

Posdinemab (JNJ-63733657) is a humanized IgG1/κ monoclonal antibody that selectively targets phosphorylated tau (pT217). Posdinemab specifically binds to the pT217+tau epitope rich in the proline domain, blocks tau protein aggregation and seed propagation, and promotes the clearance of extracellular tau species. Posdinemab reduces the levels of free and total p217+tau in cerebrospinal fluid, thereby inhibiting the pathological propagation of tau protein and the formation of neurofibrillary tangles. Posdinemab can be used for the study of progressive supranuclear palsy syndrome and Alzheimer's disease (AD), especially for prodromal or mild AD disease .
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Cat. No.: HY-163476
CAS No.: 3060954-15-3
Target:  

PI4P5K

Research Areas:  

Inflammation/Immunology Cancer

PIP5K1C-IN-1 (Compound 30) is a potent PIP5K1C inhibitor, with an IC50 of 0.80 nM. PIP5K1C-IN-1 exhibits low total clearance in mice and high levels of kinase selectivity. PIP5K1C-IN-1 can be used for the research of cancer and chronic pain .
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Cat. No.: HY-163477
CAS No.: 3060954-34-6
Target:  

PI4P5K

Research Areas:  

Cancer

PIP5K1C-IN-2 (compound 33) is a potent and selective 4-phosphate 5-kinases 1 C (PIP5K1C) inhibitor with an IC50 value of 0.0059 µM .
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