Spock1 - sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1 Gene

Also Known as Spock; Ticn1; testican

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20745

Summary

Predicted to enable calcium ion binding activity; cysteine-type endopeptidase inhibitor activity; and metalloendopeptidase inhibitor activity. Acts upstream of or within central nervous system neuron differentiation and neuron migration. Located in neuromuscular junction; node of Ranvier; and sarcoplasm. Is expressed in several structures, including jaw; nervous system; nose; skeletal musculature; and thymus primordium. Orthologous to human SPOCK1 (SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1). [provided by Alliance of Genome Resources, Apr 2022]

Spock1 Products (5)

mRNA Protein Name
NM_001166463.1 NP_001159935.1 testican-1 isoform 3 precursor
NM_001166464.1 NP_001159936.1 testican-1 isoform 4 precursor
NM_001166465.1 NP_001159937.1 testican-1 isoform 5 precursor
NM_001166466.1 NP_001159938.1 testican-1 isoform 2 precursor
NM_009262.3 NP_033288.2 testican-1 isoform 1 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in central nervous system neuron differentiation IEP
IEP: Inferred from expression pattern
10640720 MGI
involved in neurogenesis IEP
IEP: Inferred from expression pattern
10640720 MGI
involved in neuron migration IEP
IEP: Inferred from expression pattern
10640720 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10842087 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
10842087 MGI
located in node of Ranvier IDA
IDA: Inferred from direct assay
10842087 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
8626787 MGI
located in sarcoplasm IDA
IDA: Inferred from direct assay
10842087 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

testican-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13695 SPOCK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19816 Spock1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26312 Spock1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spock1 NCBI NCBI:6695