SPOCK1 - SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Gene

Also Known as TIC1; SPOCK; TESTICAN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6695

About SPOCK1

Cytogenetic location: 5q31.2 Genomic coordinates (GRCh38): 5:136,975,298-137,499,326 (from NCBI)

This gene has 11 transcripts (splice variants), 205 orthologues and 3 paralogues. Biased expression in brain (RPKM 74.1), prostate (RPKM 36.6) and 10 other tissues.

Summary

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]

SPOCK1 Products (1)

mRNA Protein Name
NM_004598.4 NP_004589.1 testican-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
9323035 GOA
enables cysteine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
14511383 GOA
enables metalloendopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
11751414 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
12853036 GOA
involved in negative regulation of endopeptidase activity IDA
IDA: Inferred from direct assay
14511383 GOA
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
12853036 GOA
Cellular Component GO Annotation Evidence Références Source
located in extracellular space IDA
IDA: Inferred from direct assay
14511383 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPOCK1 Protein Structure

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (139 - 180)

SPARC_Ca_bdg

SPARC_Ca_bdg: Secreted protein acidic and rich in cysteine Ca binding region (196 - 304)

Thyroglobulin_1

Thyroglobulin_1: Thyroglobulin type-1 repeat (313 - 376)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 439 a.a.
Protein Preferred Names Protein Names

testican-1

  • SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1

SPOCK1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
SPOCK1 Q08629 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SPOCK1 Q08629 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SPOCK1 Q08629 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SPOCK1 Q08629 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
SPOCK1 Q08629 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
SPOCK1 Q08629 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPOCK1 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P76654 Testican 1/SPOCK1 Protein, Human (sf9, His) Q08629 (M1-W439) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 101

  • DFNB101

  • Autosomal Recessive Nonsyndromic Deafness 101

  • Autosomal Recessive Deafness 101

  • Deafness, Autosomal Recessive, 101

  • Deafness, Autosomal Recessive, Type 101
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13695 SPOCK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19816 Spock1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26312 Spock1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPOCK1 MGD MGI:105371
Canis familiaris SPOCK1 VGNC VGNC:59043
Rattus norvegicus SPOCK1 RGD RGD:1311496
Felis catus SPOCK1 VGNC VGNC:102331
Macaca mulatta SPOCK1 VGNC VGNC:84514
Others SPOCK1 NCBI