COLEC12 - collectin subfamily member 12 Gene

Also Known as CLP1; NSR2; SRCL; SCARA4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81035

About COLEC12

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:316,737-500,701 (from NCBI)

This gene has 3 transcripts (splice variants), 241 orthologues and 3 paralogues. Broad expression in placenta (RPKM 63.7), lung (RPKM 26.0) and 17 other tissues.

Summary

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on Microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018]

COLEC12 Products (1)

mRNA	Protein	Name
NM_130386.3	NP_569057.2	collectin-12

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	11564734	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	11564734	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22396535	GOA
enables scavenger receptor activity	IDA IDA: Inferred from direct assay	11564734	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in cellular response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in cellular response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	11564734	GOA
involved in phagocytosis, recognition	IDA IDA: Inferred from direct assay	11564734	GOA
acts upstream of positive effect plasma membrane raft organization	IMP IMP: Inferred from mutant phenotype	25204797	GOA
involved in toll-like receptor 3 signaling pathway	IMP IMP: Inferred from mutant phenotype	25204797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COLEC12 Protein Structure

Collagen

Lectin_C

0
200
400
600
742 a.a.

Protein Preferred Names	Protein Names
collectin-12	collectin placenta protein 1

COLEC12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COLEC12	Q5KU26	CRP	Homo sapiens	P02741	IF	26922829
Intra	COLEC12	Q5KU26	CRP	Homo sapiens	P02741	Solid Phase Assay	26922829
Intra	COLEC12	Q5KU26	SCARA3	Homo sapiens	Q6AZY7	Anti Tag CoIP	33961781
Intra	COLEC12	Q5KU26	PILRA	Homo sapiens	Q9UKJ1	SPR	22396535

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Dominant 1	MRD1 Autosomal Dominant Non-Syndromic Intellectual Disability 1 Mental Retardation, Autosomal Dominant 1 Autosomal Dominant Intellectual Developmental Disorder 1
Ehlers-Danlos Syndrome, Hypermobility Type	Ehlers-Danlos Syndrome, Type 3 Ehlers-Danlos Syndrome, Type Iii EDSHMB Eds Iii Benign Hypermobility Syndrome Ehlers-Danlos Syndrome Hypermobility Type Eds3 Type Iii Ehlers-Danlos Syndrome Ehlers-Danlos Syndrome Type 3 Es-D3
Intellectual Developmental Disorder, Autosomal Dominant 2	MRD2 Autosomal Dominant Non-Syndromic Intellectual Disability 2 Autosomal Dominant Intellectual Developmental Disorder 2 Mental Retardation, Autosomal Dominant 2
3mc Syndrome	Craniofacial-Ulnar-Renal Syndrome Malpuech Facial Clefting Syndrome Oculopalatoskeletal Syndrome Carnevale Syndrome Michels Syndrome Malpuech-Michels-Mingarelli-Carnevale Syndrome Carnevale-Krajewska-Fischetto Syndrome Craniosynostosis With Lid Anomalies Malpuech Syndrome Mingarelli Syndrome Oculo-Skeletal-Abdominal Syndrome Osa Syndrome Ptosis Of Eyelids With Diastasis Recti And Hip Dysplasia Ptosis-Strabismus-Rectus Abdominis Diastasis
Developmental And Epileptic Encephalopathy 2	Epileptic Encephalopathy, Early Infantile, 2 DEE2 Eiee2 Issx2 Developmental And Epileptic Encephalopathy, 2 Infantile Spasm Syndrome, X-Linked 2 Early Infantile Epileptic Encephalopathy 2 X-Linked Infantile Spasm Syndrome 2 Atypical Rett Syndrome Cdkl5-Related Atypical Rett Syndrome Hanefeld Variant Infantile Spasm Syndrome X-Linked 2 Rett Syndrome Early-Onset Seizure Variant Rett Syndrome Variant With Infantile Spasms Encephalopathy, Epileptic, Early Infantile, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03005	COLEC12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18881	Colec12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25372	Colec12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	COLEC12	MGD	MGI:2152907
Rattus norvegicus	COLEC12	RGD	RGD:735039
Canis familiaris	COLEC12	VGNC	VGNC:39490
Bos taurus	COLEC12	VGNC	VGNC:27579
Macaca mulatta	COLEC12	VGNC	VGNC:71181
Felis catus	COLEC12	VGNC	VGNC:80433
Others	COLEC12	NCBI