Lhx1 - LIM homeobox protein 1 Gene

Also Known as Lim1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16869

Summary

Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; generation of neurons; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; gastrulation; and regionalization. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesoderm; genitourinary system; gut; and sensory organ. Orthologous to human LHX1 (LIM homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Lhx1 Products (1)

mRNA Protein Name
NM_008498.3 NP_032524.1 LIM/homeobox protein Lhx1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IGI
IGI: Inferred from genetic interaction
17166926 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
11291865 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
26494787 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9468533 MGI
Biological Process GO Annotation Evidence References Source
involved in S-shaped body morphogenesis IMP
IMP: Inferred from mutant phenotype
17610272 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: Inferred from genetic interaction
10498685 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IMP
IMP: Inferred from mutant phenotype
15930111 MGI
acts upstream of or within anatomical structure morphogenesis IMP
IMP: Inferred from mutant phenotype
10328927 MGI
acts upstream of or within anterior/posterior axis specification IGI
IGI: Inferred from genetic interaction
10529425 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: Inferred from genetic interaction
10498685 MGI
involved in branching involved in ureteric bud morphogenesis IEP
IEP: Inferred from expression pattern
7909549 MGI
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
26494787 MGI
acts upstream of or within cell-cell signaling IGI
IGI: Inferred from genetic interaction
17664423 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IGI
IGI: Inferred from genetic interaction
17664423 MGI
acts upstream of or within cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation IGI
IGI: Inferred from genetic interaction
17664423 MGI
acts upstream of or within cerebellum development IGI
IGI: Inferred from genetic interaction
17664423 MGI
involved in cervix development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
involved in comma-shaped body morphogenesis IMP
IMP: Inferred from mutant phenotype
17610272 MGI
acts upstream of or within dorsal/ventral pattern formation IGI
IGI: Inferred from genetic interaction
10498685 MGI
acts upstream of or within ectoderm formation IGI
IGI: Inferred from genetic interaction
10498685 MGI
acts upstream of or within embryonic pattern specification IGI
IGI: Inferred from genetic interaction
10529425 MGI
involved in embryonic retina morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
18094249 MGI
involved in embryonic viscerocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
14695376 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
26494787 MGI
acts upstream of or within endoderm formation IMP
IMP: Inferred from mutant phenotype
15355796 MGI
involved in epithelium development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
acts upstream of or within forebrain regionalization IGI
IGI: Inferred from genetic interaction
10529425 MGI
acts upstream of or within gastrulation with mouth forming second IMP
IMP: Inferred from mutant phenotype
15355796 MGI
acts upstream of or within head development IGI
IGI: Inferred from genetic interaction
10529425 MGI
involved in head development IGI
IGI: Inferred from genetic interaction
15857913 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
15930111 MGI
involved in lateral motor column neuron migration IMP
IMP: Inferred from mutant phenotype
20711475 MGI
acts upstream of mesendoderm development IMP
IMP: Inferred from mutant phenotype
26494787 MGI
involved in mesonephros development IEP
IEP: Inferred from expression pattern
7909549 MGI
involved in metanephric S-shaped body morphogenesis IEP
IEP: Inferred from expression pattern
7909549 MGI
involved in metanephric renal vesicle morphogenesis IEP
IEP: Inferred from expression pattern
7909549 MGI
involved in metanephros development IEP
IEP: Inferred from expression pattern
7909549 MGI
involved in motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
20711475 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17610272 MGI
involved in nephric duct elongation IMP
IMP: Inferred from mutant phenotype
16216236 MGI
involved in nephric duct morphogenesis IMP
IMP: Inferred from mutant phenotype
16216236 MGI
involved in oviduct development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
involved in oviduct epithelium development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
involved in paramesonephric duct development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
10498685 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
15930111 MGI
involved in positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
17166926 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
11291865 MGI
involved in positive regulation of anterior head development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis IMP
IMP: Inferred from mutant phenotype
16216236 MGI
involved in positive regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
11291865 MGI
involved in positive regulation of gastrulation IMP
IMP: Inferred from mutant phenotype
11291865 MGI
involved in positive regulation of nephron tubule epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
16216236 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
17664423 MGI
acts upstream of or within primitive streak formation IMP
IMP: Inferred from mutant phenotype
11291865 MGI
involved in primitive streak formation IMP
IMP: Inferred from mutant phenotype
11291865 MGI
involved in pronephros development IEP
IEP: Inferred from expression pattern
7909549 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
10328927 MGI
involved in renal vesicle morphogenesis IMP
IMP: Inferred from mutant phenotype
17610272 MGI
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
10741426 MGI
involved in retina layer formation IEP
IEP: Inferred from expression pattern
10741426 MGI
involved in retina layer formation IMP
IMP: Inferred from mutant phenotype
18094249 MGI
acts upstream of or within somite rostral/caudal axis specification IMP
IMP: Inferred from mutant phenotype
11291865 MGI
involved in spinal cord association neuron differentiation IGI
IGI: Inferred from genetic interaction
17166926 MGI
involved in spinal cord development IEP
IEP: Inferred from expression pattern
7909549 MGI
involved in telencephalon development IEP
IEP: Inferred from expression pattern
7909549 MGI
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15857913 MGI
acts upstream of or within ureter morphogenesis IGI
IGI: Inferred from genetic interaction
21731775 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
15930111 MGI
acts upstream of or within urogenital system development IMP
IMP: Inferred from mutant phenotype
15930111 MGI
involved in uterine epithelium development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
involved in uterus development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
involved in vagina development IMP
IMP: Inferred from mutant phenotype
14695376 MGI
involved in ventral spinal cord development IEP
IEP: Inferred from expression pattern
20711475 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
10482234 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8793615 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
15857913 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
26494787 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

LIM/homeobox protein Lhx1

  • LIM homeo box protein 1

  • homeobox protein Lim-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07631 LHX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21365 Lhx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27884 Lhx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lhx1 NCBI NCBI:3975