Stxbp1 - syntaxin binding protein 1 Gene

Also Known as Sec1; nSec1; NSEC1A; n-sec1; rbSec1; ANC18HA; Unc18-1; rbSec1A; rbSec1B; Munc18-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25558

Summary

Enables several functions, including enzyme binding activity; identical protein binding activity; and syntaxin-1 binding activity. Involved in several processes, including positive regulation of secretion by cell; positive regulation of vesicle docking; and regulation of protein-containing complex assembly. Acts upstream of or within protein stabilization. Located in several cellular components, including axon; perinuclear region of cytoplasm; and postsynapse. Part of protein-containing complex. Colocalizes with plasma membrane. Human ortholog(s) of this gene implicated in West syndrome and developmental and epileptic encephalopathy 4. Orthologous to human STXBP1 (syntaxin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Stxbp1 Products (1)

mRNA	Protein	Name
NM_013038.4	NP_037170.1	syntaxin-binding protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	18201107	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17442889	RGD
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	21193638	RGD
enables phospholipase binding	IDA IDA: Inferred from direct assay	14744865	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9395480	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	19255244	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12963086	RGD
enables syntaxin binding	IDA IDA: Inferred from direct assay	12506202	RGD
enables syntaxin-1 binding	IDA IDA: Inferred from direct assay	7553862	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in developmental process involved in reproduction	IMP IMP: Inferred from mutant phenotype	16951547	RGD
involved in negative regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	12093152	RGD
involved in positive regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	20801887	RGD
involved in positive regulation of glutamate secretion, neurotransmission	IMP IMP: Inferred from mutant phenotype	16951547	RGD
involved in positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	23487749	RGD
involved in positive regulation of vesicle docking	IDA IDA: Inferred from direct assay	22810233	RGD
acts upstream of or within protein stabilization	IDA IDA: Inferred from direct assay	15935055	RGD
involved in regulation of synaptic vesicle priming	IDA IDA: Inferred from direct assay	21689256	RGD
involved in regulation of synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	19255244	RGD
involved in regulation of vesicle fusion	IDA IDA: Inferred from direct assay	24532794	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16951547	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	15869823	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	17442889	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15869823	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	17442889	RGD
located in postsynapse	IDA IDA: Inferred from direct assay	15869823	RGD
located in presynapse	IDA IDA: Inferred from direct assay	15869823	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19255244	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
syntaxin-binding protein 1	p67 protein unc-18 homolog 1 protein unc-18 homolog A unc-18 homolog unc-18-1 unc-18A

Stxbp1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Stxbp1	P61765	Apba2	Rattus norvegicus	O35431	Y2H	9395480
Intra	Stxbp1	P61765	Stx1a	Rattus norvegicus	P32851	Crosslink	17301226
Intra	Stxbp1	P61765	Stx1a	Rattus norvegicus	P32851	ITC	18337752
Intra	Stxbp1	P61765	Stx1a	Rattus norvegicus	P32851	Fluorescence	18337752
Cross	Stxbp1	P61765	Stx4	Mus musculus	P70452	ITC	21193638
Cross	Stxbp1	P61765	Stx4	Mus musculus	P70452	X-Ray Diffraction	21193638
Intra	Stxbp1	P61765	Apba1	Rattus norvegicus	O35430	Y2H	9395480
Intra	Stxbp1	P61765	Apba1	Rattus norvegicus	O35430	Pull Down	9395480

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13989	STXBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21950	Stxbp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28467	Stxbp1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stxbp1	NCBI	NCBI:6812