Stx1a - syntaxin 1A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116470

Summary

Enables several functions, including ATP-dependent protein binding activity; calcium-dependent protein binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; positive regulation of secretion by cell; and synaptic vesicle exocytosis. Located in several cellular components, including actomyosin; presynaptic active zone membrane; and secretory vesicle. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in glutamatergic synapse. Is integral component of presynaptic membrane and integral component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease and Hirschsprung's disease. Orthologous to human STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Apr 2022]

Stx1a Products (1)

mRNA Protein Name
NM_053788.3 NP_446240.2 syntaxin-1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP-dependent protein binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables SNARE binding IDA
IDA: Inferred from direct assay
7553862 RGD
enables SNARE binding IPI
IPI: Inferred from physical interaction
7698987 RGD
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables myosin binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables myosin head/neck binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
8567678 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
16030255 RGD
enables protein-macromolecule adaptor activity IPI
IPI: Inferred from physical interaction
16030255 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
17301173 RGD
Biological Process GO Annotation Evidence References Source
involved in SNARE complex assembly IMP
IMP: Inferred from mutant phenotype
9671503 RGD
involved in modulation of excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
18703708 RGD
involved in positive regulation of calcium ion-dependent exocytosis IDA
IDA: Inferred from direct assay
17301173 RGD
involved in positive regulation of catecholamine secretion IDA
IDA: Inferred from direct assay
20484665 RGD
involved in positive regulation of exocytosis IDA
IDA: Inferred from direct assay
11331586 RGD
involved in positive regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
12183029 RGD
involved in positive regulation of norepinephrine secretion IDA
IDA: Inferred from direct assay
18167541 RGD
involved in protein localization to membrane IDA
IDA: Inferred from direct assay
12093152 RGD
involved in regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
16030255 RGD
involved in response to gravity IDA
IDA: Inferred from direct assay
15076716 RGD
involved in synaptic vesicle docking IEP
IEP: Inferred from expression pattern
1321498 RGD
involved in synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
7901002 RGD
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
7901002 RGD
involved in synaptic vesicle exocytosis IEP
IEP: Inferred from expression pattern
7901002 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
26903802 RGD
located in actomyosin IDA
IDA: Inferred from direct assay
16030255 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
7901002 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
7901002 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
17301173 RGD
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
26903802 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
26903802 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
8301329 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
12093152 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
19255244 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
15537656 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
7860636 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
14645230 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
IDA: Inferred from direct assay
7553862 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex IMP
IMP: Inferred from mutant phenotype
9671503 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA
IDA: Inferred from direct assay
7553862 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IDA
IDA: Inferred from direct assay
19132534 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
17301173 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

syntaxin-1A

  • P35A

  • neuron-specific antigen HPC-1

  • synaptotagmin-associated 35 kDa protein

  • syntaxin 1A (brain)

  • syntaxin 1A (brain)-like

Stx1a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Stx1a P32851 SNAP47 Homo sapiens Q5SQN1
Confocal
26359495
Cross
Stx1a P32851 SNAP47 Homo sapiens Q5SQN1
Anti Tag CoIP
26359495
Intra
Stx1a P32851 Snap25 Rattus norvegicus P60881
Pull Down
21193638
Intra
Stx1a P32851 Snap25 Rattus norvegicus P60881
Anti Bait CoIP
17717530
Intra
Stx1a P32851 Snap25 Rattus norvegicus P60881
EPR
26876096
Intra
Stx1a P32851 Snap25 Rattus norvegicus P60881
Anti Bait CoIP
20489724
Intra
Stx1a P32851 Snap25 Rattus norvegicus P60881
Pull Down
10373452
Intra
Stx1a P32851 Stxbp1 Rattus norvegicus P61765
EPR
26876096
Intra
Stx1a P32851 Stxbp1 Rattus norvegicus P61765
X-Ray Diffraction
10746715
Intra
Stx1a P32851 Stxbp1 Rattus norvegicus P61765
Fluorescence
18337752
Intra
Stx1a P32851 Stxbp1 Rattus norvegicus P61765
ITC
21193638
Intra
Stx1a P32851 Stxbp1 Rattus norvegicus P61765
Anti Tag CoIP
26359495
Intra
Stx1a P32851 Stxbp1 Rattus norvegicus P61765
ITC
18337752
Intra
Stx1a P32851 Stxbp1 Rattus norvegicus P61765
Pull Down
21193638
Intra
Stx1a P32851 Snap25 Rattus norvegicus P60881-2
FRET
18275821
Intra
Stx1a P32851 Cadps Rattus norvegicus Q62717
Density Sedimentation
19805029
Cross
Stx1a P32851 Snap25 Mus musculus P60879
Comigration in SDS
19805029
Cross
Stx1a P32851 Snap25 Mus musculus P60879
Anti Bait CoIP
19703397
Intra
Stx1a P32851 Vamp2 Rattus norvegicus P63045
Pull Down
21193638
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13980 STX1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stx1a NCBI NCBI:6804