Snap25 - synaptosomal-associated protein 25 Gene

Also Known as sp; Bdr; SUP; GENA70; SNAP-25

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20614

Summary

Enables syntaxin-1 binding activity. Involved in exocytosis; neurotransmitter receptor internalization; and regulation of neuron projection development. Acts upstream of or within several processes, including associative learning; neurotransmitter secretion; and regulation of synaptic plasticity. Located in several cellular components, including glutamatergic synapse; synaptic vesicle; and trans-Golgi network. Is extrinsic component of cytoplasmic side of plasma membrane. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex. Is expressed in adrenal gland; jaw; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; obesity; schizophrenia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Down syndrome and congenital myasthenic syndrome 18. Orthologous to human SNAP25 (synaptosome associated protein 25). [provided by Alliance of Genome Resources, Apr 2022]

Snap25 Products (24)

mRNA Protein Name
NM_001291056.2 NP_001277985.1 synaptosomal-associated protein 25 isoform b
NM_001355254.1 NP_001342183.1 synaptosomal-associated protein 25 isoform a
NM_001355255.2 NP_001342184.1 synaptosomal-associated protein 25 isoform c
NM_001412615.1 NP_001399544.1 synaptosomal-associated protein 25 isoform a
NM_001412616.1 NP_001399545.1 synaptosomal-associated protein 25 isoform a
NM_001412617.1 NP_001399546.1 synaptosomal-associated protein 25 isoform b
NM_001412618.1 NP_001399547.1 synaptosomal-associated protein 25 isoform c
NM_001412619.1 NP_001399548.1 synaptosomal-associated protein 25 isoform d
NM_001412620.1 NP_001399549.1 synaptosomal-associated protein 25 isoform d
NM_001412621.1 NP_001399550.1 synaptosomal-associated protein 25 isoform e
NM_001412622.1 NP_001399551.1 synaptosomal-associated protein 25 isoform f
NM_011428.4 NP_035558.1 synaptosomal-associated protein 25 isoform a
NM_001291056.2 NP_001277985.1 synaptosomal-associated protein 25 isoform b
NM_001355254.1 NP_001342183.1 synaptosomal-associated protein 25 isoform a
NM_001355255.2 NP_001342184.1 synaptosomal-associated protein 25 isoform c
NM_001412615.1 NP_001399544.1 synaptosomal-associated protein 25 isoform a
NM_001412616.1 NP_001399545.1 synaptosomal-associated protein 25 isoform a
NM_001412617.1 NP_001399546.1 synaptosomal-associated protein 25 isoform b
NM_001412618.1 NP_001399547.1 synaptosomal-associated protein 25 isoform c
NM_001412619.1 NP_001399548.1 synaptosomal-associated protein 25 isoform d
NM_001412620.1 NP_001399549.1 synaptosomal-associated protein 25 isoform d
NM_001412621.1 NP_001399550.1 synaptosomal-associated protein 25 isoform e
NM_001412622.1 NP_001399551.1 synaptosomal-associated protein 25 isoform f
NM_011428.4 NP_035558.1 synaptosomal-associated protein 25 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SNAP receptor activity IDA
IDA: Inferred from direct assay
12145198 MGI
enables SNARE binding IDA
IDA: Inferred from direct assay
12145198 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16565726 MGI
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
18703708 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within associative learning IMP
IMP: Inferred from mutant phenotype
23064108 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
23064108 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
23395379 MGI
acts upstream of or within neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
11753414 MGI
involved in presynaptic dense core vesicle exocytosis IDA
IDA: Inferred from direct assay
28404788 MGI
involved in presynaptic dense core vesicle exocytosis IEP
IEP: Inferred from expression pattern
28404788 MGI
involved in presynaptic dense core vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
28404788 MGI
acts upstream of or within regulation of establishment of protein localization IMP
IMP: Inferred from mutant phenotype
23395379 MGI
involved in regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
21986494 MGI
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
17728451 MGI
involved in synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
17728451 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21576241 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
23821748 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
19546860 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17728451 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17728451 MGI
located in membrane IDA
IDA: Inferred from direct assay
19546860 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
14622145 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18827011 MGI
located in presynaptic membrane IDA
IDA: Inferred from direct assay
24680688 MGI
located in ribbon synapse IDA
IDA: Inferred from direct assay
24680688 MGI
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
21576241 MGI
located in synapse IDA
IDA: Inferred from direct assay
10712642 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
24680688 MGI
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA
IDA: Inferred from direct assay
21040848 MGI
located in trans-Golgi network IDA
IDA: Inferred from direct assay
18827011 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptosomal-associated protein 25

  • blind drunk

  • super protein

  • synaptosomal-associated 25 kDa protein

  • synaptosomal-associated protein, 25 kDa

Snap25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Snap25 P60879 Cenpf Mus musculus Q155P7
Anti Bait CoIP
16672379
Intra
Snap25 P60879 Cenpf Mus musculus Q155P7
Fluorescence
18827011
Intra
Snap25 P60879 Cenpf Mus musculus Q155P7
Confocal
16672379
Intra
Snap25 P60879 Cenpf Mus musculus Q155P7
Y2H
16672379
Intra
Snap25 P60879 Cenpf Mus musculus Q155P7
Anti Tag CoIP
16672379
Intra
Snap25 P60879 Stx1a Mus musculus O35526
Anti Bait CoIP
20114047
Intra
Snap25 P60879 Stx1a Mus musculus O35526
Anti Bait CoIP
24705552
Intra
Snap25 P60879 Vamp2 Mus musculus P63044
Comigration in SDS
19703397
Intra
Snap25 P60879 Vamp2 Mus musculus P63044
Anti Bait CoIP
24705552
Intra
Snap25 P60879 Vamp2 Mus musculus P63044
Anti Bait CoIP
20114047
Intra
Snap25 P60879 Vamp2 Mus musculus P63044
Comigration in SDS
19805029
Intra
Snap25 P60879 Vamp2 Mus musculus P63044
Anti Bait CoIP
20798282
Intra
Snap25 P60879 Vamp2 Mus musculus P63044
Density Sedimentation
16565726
Cross
Snap25 P60879 Stx1a Rattus norvegicus P32851
Affinity Techniques
19703397
Cross
Snap25 P60879 Stx1a Rattus norvegicus P32851
Density Sedimentation
16565726
Cross
Snap25 P60879 Stx1a Rattus norvegicus P32851
Comigration in SDS
19703397
Cross
Snap25 P60879 Stx1a Rattus norvegicus P32851
Comigration in SDS
19805029
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13474 SNAP25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-182539 DD04107 Modulator / Unkown
HY-RS17856 Snap25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24325 Snap25 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Snap25 NCBI NCBI:6616