TAFA5 - TAFA chemokine like family member 5 Gene

Also Known as TAFA-5; FAM19A5; UNQ5208; QLLK5208

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25817

About TAFA5

Cytogenetic location: 22q13.32 Genomic coordinates (GRCh38): 22:48,489,553-48,751,932 (from NCBI)

This gene has 5 transcripts (splice variants) and 233 orthologues. Biased expression in brain (RPKM 13.2), endometrium (RPKM 3.4) and 8 other tissues.

Summary

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]

TAFA5 Products (2)

mRNA Protein Name
NM_001082967.3 NP_001076436.1 chemokine-like protein TAFA-5 isoform 1 precursor
NM_015381.7 NP_056196.2 chemokine-like protein TAFA-5 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor binding IPI
IPI: Inferred from physical interaction
29453251 GOA
enables receptor ligand activity IPI
IPI: Inferred from physical interaction
29453251 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
29453251 GOA
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
29453251 GOA
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
29453251 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
29453251 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAFA5 Protein Structure

TAFA

TAFA: TAFA family (42 - 131)

  • 0
  • 100
  • 132 a.a.
Protein Preferred Names Protein Names

chemokine-like protein TAFA-5

  • TAFA protein 5

Recombinant TAFA5 Proteins

Cat. No. Product Name Accession Purity
HY-P700984 TAFA5/FAM19A5 Protein, Human (His) NP_056196 (T37-S125) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14183 TAFA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22846 Tafa5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29360 Tafa5 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TAFA5 VGNC VGNC:65941
Canis familiaris TAFA5 VGNC VGNC:108221
Bos taurus TAFA5 VGNC VGNC:28779
Rattus norvegicus TAFA5 RGD RGD:1562115
Mus musculus TAFA5 MGD MGI:2146182
Others TAFA5 NCBI