GNG3 - G protein subunit gamma 3 Gene

Also Known as HG3D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2785

About GNG3

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,706,446-62,709,201 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 11 paralogues. Biased expression in brain (RPKM 92.3), adrenal (RPKM 8.1) and 1 other tissue.

Summary

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]

GNG3 Products (1)

mRNA Protein Name
NM_012202.5 NP_036334.1 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26900580 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNG3 Protein Structure

G-gamma

G-gamma: GGL domain (14 - 74)

  • 0
  • 75 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

  • NBP gamma-3

GNG3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GNG3 P63215 TRIM74 Homo sapiens Q86UV6-2
Validated Y2H
32296183
Intra
GNG3 P63215 SS18L2 Homo sapiens Q9UHA2
Validated Y2H
32296183
Intra
GNG3 P63215 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Lipodystrophy, Congenital Generalized, Type 2

  • Congenital Generalized Lipodystrophy Type 2

  • CGL2

  • Berardinelli-Seip Congenital Lipodystrophy Type 2

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome Bscl2-Related

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Berardinelli-Seip Congenital Lipodystrophy, Type 2

  • Seip Syndrome

  • Berardinelli Syndrome

  • Lipodystrophy, Total, And Acromegaloid Gigantism

  • Lipoatrophic Diabetes, Congenital

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 2

  • Brunzell Syndrome, Bscl2-Related

  • Congenital Lipoatrophic Diabetes

  • Congenital Generalized Lipodystrophy 2

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05557 GNG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22191 Gng3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28713 Gng3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GNG3 MGD MGI:102704
Bos taurus GNG3 VGNC VGNC:29466
Canis familiaris GNG3 VGNC VGNC:41320
Rattus norvegicus GNG3 RGD RGD:620805
Macaca mulatta GNG3 VGNC VGNC:101090
Others GNG3 NCBI