HLA-DMA - major histocompatibility complex, class II, DM alpha Gene

Also Known as DMA; HLADM; RING6; D6S222E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3108

About HLA-DMA

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,948,618-32,953,097 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 111 orthologues and 13 paralogues. Broad expression in lymph node (RPKM 124.3), lung (RPKM 102.4) and 24 other tissues.

Summary

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-DMA Products (1)

mRNA Protein Name
NM_006120.4 NP_006111.2 HLA class II histocompatibility antigen, DM alpha chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables MHC class II protein complex binding IDA
IDA: Inferred from direct assay
9075930 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21131964 GOA
Biological Process GO Annotation Evidence References Source
involved in peptide antigen assembly with MHC class II protein complex IDA
IDA: Inferred from direct assay
7606781 GOA
Cellular Component GO Annotation Evidence References Source
part of MHC class II protein complex IDA
IDA: Inferred from direct assay
7606781 GOA
located in cell surface IDA
IDA: Inferred from direct assay
22247549 GOA
located in late endosome membrane IDA
IDA: Inferred from direct assay
9075930 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
9075930 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DMA Protein Structure

MHC_II_alpha

MHC_II_alpha: Class II histocompatibility antigen, alpha domain (41 - 123)

C1-set

C1-set: Immunoglobulin C1-set domain (135 - 207)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

HLA class II histocompatibility antigen, DM alpha chain

  • MHC class II antigen DMA

HLA-DMA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HLA-DMA P28067 HLA-DMB Homo sapiens P28068
X-Ray Diffraction
23222639
Intra
HLA-DMA P28067 HLA-DMB Homo sapiens P28068
Anti Tag CoIP
23222639
Intra
HLA-DMA P28067 HLA-DMB Homo sapiens P28068
SPR
21131964
Intra
HLA-DMA P28067 HLA-DMB Homo sapiens P28068
GMS
23222639
Intra
HLA-DMA P28067 HLA-DMB Homo sapiens P28068
FPS
21131964
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HLA-DMA Proteins

Cat. No. Product Name Accession Purity
HY-P71463 HLA-DMA Protein, Human (His) Q6ICR9 (V27-C233) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chediak-Higashi Syndrome

  • CHS

  • Chédiak-Higashi Syndrome

  • Chediak - Steinbrinck Anomaly

  • Chediak Higashi Syndrome

  • Chediak-Steinbrinck-Higashi Syndrome

  • Oculocutaneous Albinism With Leukocyte Defect

  • Chediak-Higashi Disease

  • Chediak-Higashi-Steinbrink Syndrome
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Severe Combined Immunodeficiency

  • Scid

  • Severe Combined Immunodeficiency Disease

  • Combined T And B Cell Inborn Immunodeficiency

  • Immunodeficiency, Severe Combined

  • Scid - [Severe Combined Immunodeficiencies]
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06199 HLA-DMA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HLA-DMA RGD RGD:735053
Mus musculus HLA-DMA MGD MGI:95921