PPARD - peroxisome proliferator activated receptor delta Gene

Also Known as FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5467

About PPARD

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,342,558-35,428,178 (from NCBI)

This gene has 5 transcripts (splice variants), 421 orthologues and 18 paralogues. Ubiquitous expression in placenta (RPKM 13.1), thyroid (RPKM 10.8) and 25 other tissues.

Summary

This gene encodes a member of the Peroxisome Proliferator-activated Receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal Cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]

PPARD Products (35)

mRNA Protein Name
XM_047418931.1 XP_047274887.1 peroxisome proliferator-activated receptor delta isoform X1
NM_001171818.2 NP_001165289.1 peroxisome proliferator-activated receptor delta isoform 1
XM_006715123.2 XP_006715186.1 peroxisome proliferator-activated receptor delta isoform X1
XM_011514710.2 XP_011513012.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418920.1 XP_047274876.1 peroxisome proliferator-activated receptor delta isoform X1
NM_001171819.2 NP_001165290.1 peroxisome proliferator-activated receptor delta isoform 3
XM_017010973.2 XP_016866462.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418932.1 XP_047274888.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418933.1 XP_047274889.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418934.1 XP_047274890.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418926.1 XP_047274882.1 peroxisome proliferator-activated receptor delta isoform X1
XM_005249193.2 XP_005249250.1 peroxisome proliferator-activated receptor delta isoform X1
NM_006238.5 NP_006229.1 peroxisome proliferator-activated receptor delta isoform 1
XM_024446474.2 XP_024302242.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418915.1 XP_047274871.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418919.1 XP_047274875.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418935.1 XP_047274891.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418918.1 XP_047274874.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418936.1 XP_047274892.1 peroxisome proliferator-activated receptor delta isoform X2
XM_047418924.1 XP_047274880.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418923.1 XP_047274879.1 peroxisome proliferator-activated receptor delta isoform X1
XM_017010974.2 XP_016866463.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418922.1 XP_047274878.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418927.1 XP_047274883.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418921.1 XP_047274877.1 peroxisome proliferator-activated receptor delta isoform X1
NM_001171820.2 NP_001165291.1 peroxisome proliferator-activated receptor delta isoform 4
XM_047418917.1 XP_047274873.1 peroxisome proliferator-activated receptor delta isoform X1
NM_177435.3 NP_803184.1 peroxisome proliferator-activated receptor delta isoform 2
XM_047418930.1 XP_047274886.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418928.1 XP_047274884.1 peroxisome proliferator-activated receptor delta isoform X1
XM_011514707.2 XP_011513009.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418925.1 XP_047274881.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418929.1 XP_047274885.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418916.1 XP_047274872.1 peroxisome proliferator-activated receptor delta isoform X1
XM_047418937.1 XP_047274893.1 peroxisome proliferator-activated receptor delta isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12955147 GOA
enables linoleic acid binding IDA
IDA: Inferred from direct assay
10198642 GOA
enables lipid binding IDA
IDA: Inferred from direct assay
12955147 GOA
enables nuclear receptor activity IDA
IDA: Inferred from direct assay
12955147 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15722453 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
15001550 GOA
Biological Process GO Annotation Evidence References Source
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
12909723 GOA
involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
11551955 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
35675826 GOA
involved in energy homeostasis IDA
IDA: Inferred from direct assay
35675826 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12955147 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
35675826 GOA
Cellular Component GO Annotation Evidence References Source
is active in nucleus IDA
IDA: Inferred from direct assay
35675826 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPARD Protein Structure

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (73 - 139)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (239 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor delta

  • PPAR-beta

  • PPAR-delta

  • PPARD/MYO1D fusion

  • nuclear hormone receptor 1

  • nuclear receptor subfamily 1 group C member 2

  • peroxisome proliferator-activated receptor beta

PPARD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPARD Q03181 KDM1A Homo sapiens O60341
Anti Tag CoIP
23455924
Intra
PPARD Q03181 KDM1A Homo sapiens O60341
Y2H
23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

PPARD Antibodies

Cat. No. Product Name Application Reactivity
HY-P85753 PPAR Delta Antibody (YA5445) ICC/IF, IHC-P Human, Rat, Mouse

Related Diseases

Diseases Alias
Diabetes Mellitus

  • Diabetes
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Diabetes Mellitus, Non-Insulin-Dependent

  • Type 2 Diabetes

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Abdominal Obesity-Metabolic Syndrome 1

  • Metabolic Syndrome X

  • Metabolic Syndrome

  • AOMS1

  • Dysmetabolic Syndrome X

  • Metabolic Disease

  • Abdominal Obesity Metabolic Syndrome
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2

  • Abdominal Obesity-Metabolic Syndrome

  • Abdominal Obesity Metabolic Syndrome

  • Metabolic Syndrome X

  • Aoms2

  • Aoms1
Skin Disease

  • Skin Diseases

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Genodermatosis

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Lipid Metabolism Disorder

  • Dyslipidemia

  • Disorder Of Fatty Acid Metabolism

  • Lipid Metabolism Disorders

  • Fatty Acid Metabolism Disorder

  • Disorder Of Lipid Metabolism

  • Abnormality Of Lipid Metabolism

  • Lipid Metabolism, Inborn Errors

  • Dyslipidemias

  • Disorders Of Lipid Metabolism

  • Congenital Disorders Of Lipid Metabolism

  • Inherited Disorders Of Lipid Metabolism
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Obesity , Susceptibility To

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Cardiovascular System Disease

  • Abnormality Of The Cardiovascular System

  • Disease Of Subdivision Of Hemolymphoid System

  • Disorder Of Cardiovascular System

  • Cardiovascular Diseases

  • Cardiovascular Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10922 PPARD Human Pre-designed siRNA Set A / Unkown
HY-RS10923 Ppard Mouse Pre-designed siRNA Set A / Unkown
HY-121579 L-764406 Agonist / Unkown
HY-RS10924 Ppard Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PPARD VGNC VGNC:68976
Rattus norvegicus PPARD RGD RGD:3370
Bos taurus PPARD VGNC VGNC:33182
Macaca mulatta PPARD VGNC VGNC:76228
Canis familiaris PPARD VGNC VGNC:44835
Mus musculus PPARD MGD MGI:101884
Others PPARD NCBI