PPAR Delta Antibody (YA5445)
(Synonyms: Peroxisome proliferator-activated receptor delta; PPAR-delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-beta; )
Based on 1 Customer Validation
PPAR Delta Antibody (YA5445) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PPAR Delta.
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Host:
Mouse
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Application:
ICC/IF, IHC-P
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Reactivity :
Human, Rat, Mouse
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:50-200 | 1:100-200 |
Product Details
PPAR Delta Antibody (YA5445) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PPAR Delta.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat, Mouse
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Observed Molecular WeightObserved band size: 50 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Recombinant Protein of PPAR Delta of PPAR Delta
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PPAR Delta is a Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Ubiquitous with maximal levels in placenta and skeletal muscle -
Isoforms & Post-Translational Modification
Q03181 has 4 isomers: Q03181-1: 49903 Da (predicted); Q03181-2: 40406 Da (predicted); Q03181-3: 45764 Da (predicted); Q03181-4: 38855 Da (predicted).
'Lys-48'-linked polyubiquitinated; leading to proteasomal degradation (PubMed:35675826). Deubiquitinated and stabilized by OTUD3 (PubMed:35675826) -
Subunit
Heterodimer with the retinoid X receptor. Interacts (via domain NR LBD) with CRY1 and CRY2 in a ligand-dependent manner (By similarity)
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SwissProt ID
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Synonyms
Peroxisome proliferator-activated receptor delta; PPAR-delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-beta;
Documentation
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Data Sheet (231 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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User Guide for Antibodies (1077 KB)
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