ST3GAL4 - ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Gene

Also Known as STZ; SAT3; ST-4; CGS23; SIAT4; NANTA3; SIAT4C; ST3GalIV; ST3GalA.2; gal-NAc6S

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6484

About ST3GAL4

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:126,355,686-126,414,638 (from NCBI)

This gene has 26 transcripts (splice variants), 221 orthologues and 14 paralogues. Broad expression in adrenal (RPKM 20.2), ovary (RPKM 18.9) and 23 other tissues.

Summary

This gene encodes a member of the Glycosyltransferase 29 family, a group of Enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

ST3GAL4 Products (9)

mRNA Protein Name
NM_001254757.2 NP_001241686.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2
NM_001254758.2 NP_001241687.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2
NM_001254759.2 NP_001241688.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 3 precursor
NM_001348396.2 NP_001335325.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4
NM_001348397.2 NP_001335326.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4
NM_001348398.2 NP_001335327.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 5 precursor
NM_001348399.2 NP_001335328.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2
NM_001348400.2 NP_001335329.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1 precursor
NM_006278.3 NP_006269.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IDA
IDA: Inferred from direct assay
8611500 GOA
enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IMP
IMP: Inferred from mutant phenotype
25498912 GOA
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase IDA
IDA: Inferred from direct assay
8288606 GOA
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
IDA: Inferred from direct assay
8288606 GOA
Biological Process GO Annotation Evidence References Source
involved in cognition IMP
IMP: Inferred from mutant phenotype
23227193 GOA
involved in glycolipid biosynthetic process IDA
IDA: Inferred from direct assay
8288606 GOA
involved in glycoprotein biosynthetic process IDA
IDA: Inferred from direct assay
8288606 GOA
involved in lipid glycosylation IDA
IDA: Inferred from direct assay
8288606 GOA
involved in oligosaccharide biosynthetic process IDA
IDA: Inferred from direct assay
8288606 GOA
involved in positive regulation of leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
25498912 GOA
involved in protein glycosylation IDA
IDA: Inferred from direct assay
8288606 GOA
involved in protein sialylation IDA
IDA: Inferred from direct assay
8288606 GOA
involved in sialylation IDA
IDA: Inferred from direct assay
8288606 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST3GAL4 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (83 - 331)

  • 0
  • 100
  • 200
  • 300
  • 333 a.a.
Protein Preferred Names Protein Names

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

  • N-acetyllactosaminide alpha-2,3-sialyltransferase

Recombinant ST3GAL4 Proteins

Cat. No. Product Name Accession Purity
HY-P77849 ST3GAL4 Protein, Human (HEK293, His-HA) Q11206 (E41-F333) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Hyperglycemia
Developmental And Epileptic Encephalopathy 15

  • DEE15

  • Epileptic Encephalopathy, Early Infantile, 15

  • Eiee15

  • Developmental And Epileptic Encephalopathy, 15

  • Early Infantile Epileptic Encephalopathy 15

  • Encephalopathy, Epileptic, Early Infantile, Type 15

  • Early Infantile Epileptic Encephalopathy With Suppression Bursts

  • X-Linked Infantile Spasm Syndrome
Diabetes Mellitus

  • Diabetes
Diabetic Neuropathy

  • Diabetic Neuropathies
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13849 ST3GAL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18209 St3gal4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24686 St3gal4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ST3GAL4 VGNC VGNC:77827
Felis catus ST3GAL4 VGNC VGNC:65722
Canis familiaris ST3GAL4 VGNC VGNC:46852
Rattus norvegicus ST3GAL4 RGD RGD:1303068
Mus musculus ST3GAL4 MGD MGI:1316743
Bos taurus ST3GAL4 VGNC VGNC:35333
Others ST3GAL4 NCBI