CAPNS1 - calpain small subunit 1 Gene

Also Known as CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 826

About CAPNS1

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,140,066-36,150,353 (from NCBI)

This gene has 17 transcripts (splice variants), 296 orthologues and 20 paralogues. Ubiquitous expression in esophagus (RPKM 128.4), heart (RPKM 97.8) and 25 other tissues.

Summary

This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including Apoptosis, proliferation, migration, adhesion, and Autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

CAPNS1 Products (4)

mRNA	Protein	Name
NM_001003962.3	NP_001003962.1	calpain small subunit 1 isoform 1
NM_001302632.2	NP_001289561.1	calpain small subunit 1 isoform 1
NM_001302633.2	NP_001289562.1	calpain small subunit 1 isoform 2
NM_001749.4	NP_001740.1	calpain small subunit 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-dependent cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	17646163	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10639123	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of calpain complex	IPI IPI: Inferred from physical interaction	10639123	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14559243	GOA
located in membrane	IDA IDA: Inferred from direct assay	14559243	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPNS1 Protein Structure

EF-hand_8

EF-hand_6

0
100
200
268 a.a.

Protein Preferred Names	Protein Names
calpain small subunit 1	CANP small subunit

CAPNS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CAPNS1	P04632	RASA1	Homo sapiens	P20936	Anti Bait CoIP	18761085
Intra	CAPNS1	P04632	RASA1	Homo sapiens	P20936	Competition Binding	18761085
Intra	CAPNS1	P04632	CAPN2	Homo sapiens	P17655	CD	28319173
Intra	CAPNS1	P04632	CAPN2	Homo sapiens	P17655	X-Ray Diffraction	10639123
Intra	CAPNS1	P04632	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

CAPNS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81476	Calpain Small Subunit 1 Antibody (YA1221)	IHC-P	Human
HY-P81476A	Calpain Small Subunit 1 Antibody (YA1221)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Ulcer Of Lower Limbs	Ulcer Of Ankle Ulcer Of Calf Ulcer Of Heel And Midfoot Ulcer Of Thigh Ulcer Of Lower Limb
Limb-Girdle Muscular Dystrophy	Lgmd Limb Girdle Muscular Dystrophy Muscular Dystrophies, Limb-Girdle Erb'S Muscular Dystrophy Leyden-Mbius Muscular Dystrophy Limb-Girdle Syndrome Myopathic Limb-Girdle Syndrome Limb Girdle Muscular Dystrophy Limb-Girdle Dystrophy, Muscular, Limb-Girdle Lgmd - [Limb-Girdle Muscular Dystrophy] Limb Girdle Muscle Dystrophy Limb-Girdle Myopathy
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158022	CTSL/CAPN1-IN-1	Inhibitor	/	Unkown
HY-161342	CTSL/CAPN1-IN-2	Inhibitor	/	Unkown
HY-RS01883	CAPN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01895	CAPNS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17903	Capn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24372	Capn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CAPNS1	MGD	MGI:88266
Rattus norvegicus	CAPNS1	RGD	RGD:2270
Bos taurus	CAPNS1	VGNC	VGNC:52184
Macaca mulatta	CAPNS1	VGNC	VGNC:108488
Canis familiaris	CAPNS1	VGNC	VGNC:53676
Others	CAPNS1	NCBI