ZIKV-IN-3
ZIKV-IN-3 (compound 5a), an andrographolide derivatives, is a potent ZIKV NS5 methyl transferase (MTase) inhibitor with an IC50 value of 18.34 μM. ZIKV-IN-3 inhibits ZIKV replication and infection. ZIKV-IN-3 can be used in research of Zika virus (ZIKV).
For research use only. We do not sell to patients.
- CAS No.: 947699-46-9
- Formula: C39H41NO4
- Molecular Weight:587.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA Methyltransferase Isoforms
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Biological Activity
IC50: 18.34 μM (MTase)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | CC50 |
>200 μM
Compound: 5a
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Cytotoxicity against human A549 cells incubated for 96 hrs
Cytotoxicity against human A549 cells incubated for 96 hrs
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[PMID: 36055002] |
| Huh-7 | CC50 |
>200 μM
Compound: 5a
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Cytotoxicity against human Huh-7 cells incubated for 96 hrs
Cytotoxicity against human Huh-7 cells incubated for 96 hrs
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[PMID: 36055002] |
| Vero | CC50 |
>200 μM
Compound: 5a
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Cytotoxicity against african green monkey Vero cells incubated for 96 hrs
Cytotoxicity against african green monkey Vero cells incubated for 96 hrs
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[PMID: 36055002] |
ZIKV-IN-2 (compound 5a; 0.08-50 μM) inhibits ZIKV-induced plaque formation with an EC50 value of 0.76 μM and has anti-ZIKV effect with EC50 values of 0.48, 0.37, and 0.45 μM for Vero, Huh7 and A549 cells, respectively[1].
ZIKV-IN-2 (0.08-50 μM; 48 h) inhibits the expression of ZIKV E protein with an EC50 value of 0.38 μM and inhibits ZIKV replication and infection[1].
ZIKV-IN-2 (0.08-50 μM; 96 h) has low cytotoxicity in Vero, Huh7 and A549 cells[1].
Vero, Huh7 and A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Vero, Huh7 and A549 cells
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Concentration:0.08, 0.4, 2, 10, and 50 μM
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Incubation Time:96 hours
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Result:Exhibited low cytotoxicities to Vero cells, Huh7 cells and A549 cells with CC50>200 μM to all three cell lines.
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Cell Line:Vero cells
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Concentration:0.08, 0.4, 2, 10, and 50 μM
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Incubation Time:48 hours
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Result:Inhibited the expression of ZIKV E protein in a dose-dependent manner.
Chemical Information
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CAS No. 947699-46-9
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Molecular Weight 587.75
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Formula C39H41NO4
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SMILES
O=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@@](COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)(C)/C(CC[C@@]23C)=N/O)=C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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