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NHSL2 - NHS like 2 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 340527

About NHSL2

This gene has 8 transcripts (splice variants), 216 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 1.5), fat (RPKM 1.1) and 24 other tissues.

Summary

Predicted to enable calcium ion binding activity. Predicted to be involved in cell differentiation. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NHSL2 Products (1)

mRNA	Protein	Name
NM_001013627.3	NP_001013649.2	NHS-like protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NHSL2 Protein Structure

NHS

0
200
400
600
800
844 a.a.

Protein Preferred Names	Protein Names
NHS-like protein 2	TPT1-like protein

NHSL2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NHSL2	Q5HYW2	PIH1D2	Homo sapiens	Q8WWB5	Validated Y2H	32296183
Intra	NHSL2	Q5HYW2	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	PPP1R13B	Homo sapiens	Q96KQ4	Validated Y2H	32296183
Intra	NHSL2	Q5HYW2	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	PPP1R13B	Homo sapiens	Q96KQ4	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	ABI2	Homo sapiens	Q9NYB9-2	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	NHSL2	Q5HYW2	ABI2	Homo sapiens	Q9NYB9-2	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	ABI2	Homo sapiens	Q9NYB9-2	Anti Tag CoIP	28514442
Intra	NHSL2	Q5HYW2	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	NHSL2	Q5HYW2	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	ABI1	Homo sapiens	Q8IZP0-5	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	ABI1	Homo sapiens	Q8IZP0-5	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	ABI1	Homo sapiens	Q8IZP0-5	Validated Y2H	32296183
Intra	NHSL2	Q5HYW2	DYNLT1	Homo sapiens	P63172	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	DYNLT1	Homo sapiens	P63172	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	CTTN	Homo sapiens	Q14247-3	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	CTTN	Homo sapiens	Q14247-3	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	YWHAH	Homo sapiens	Q04917	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	YWHAH	Homo sapiens	Q04917	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	BTRC	Homo sapiens	Q9Y297	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	BTRC	Homo sapiens	Q9Y297	Validated Y2H	32296183
Intra	NHSL2	Q5HYW2	BTRC	Homo sapiens	Q9Y297	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	CLIC1	Homo sapiens	O00299	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	CLIC1	Homo sapiens	O00299	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	YWHAG	Homo sapiens	P61981	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	YWHAG	Homo sapiens	P61981	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	NCK1	Homo sapiens	P16333	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	NCK1	Homo sapiens	P16333	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	PLK1	Homo sapiens	P53350	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	PLK1	Homo sapiens	P53350	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	NCK2	Homo sapiens	O43639	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	TFCP2	Homo sapiens	Q12800	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	NHSL2	Q5HYW2	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	NHSL2	Q5HYW2	ABI3	Homo sapiens	Q9P2A4	Y2H Array	32296183
Intra	NHSL2	Q5HYW2	ABI3	Homo sapiens	Q9P2A4	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	32296183
Intra	NHSL2	Q5HYW2	ATXN1	Homo sapiens	P54253	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nance-Horan Syndrome	NHS Cataract-Dental Syndrome Cataract, X-Linked, With Hutchinsonian Teeth Mesiodens-Cataract Syndrome Cataract X-Linked With Hutchinsonian Teeth Cataract Dental Syndrome Mesiodens Cataract Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09292	NHSL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NHSL2	VGNC	VGNC:32073
Mus musculus	NHSL2	MGD	MGI:3645090
Rattus norvegicus	NHSL2	RGD	RGD:1564117
Canis familiaris	NHSL2	VGNC	VGNC:43806
Felis catus	NHSL2	VGNC	VGNC:108369
Others	NHSL2	NCBI