SCAPER - S-phase cyclin A associated protein in the ER Gene

Also Known as IDDRP; ZNF291; Zfp291; MSTP063

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 49855

About SCAPER

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:76,347,904-76,905,340 (from NCBI)

This gene has 23 transcripts (splice variants), 211 orthologues and is associated with 5 phenotypes. Broad expression in testis (RPKM 4.5), brain (RPKM 3.0) and 25 other tissues.

Summary

Predicted to enable nucleic acid binding activity and zinc ion binding activity. Located in cytosol and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

SCAPER Products (6)

mRNA Protein Name
NM_001145923.2 NP_001139395.1 S phase cyclin A-associated protein in the endoplasmic reticulum isoform b
NM_001353009.2 NP_001339938.1 S phase cyclin A-associated protein in the endoplasmic reticulum isoform c
NM_001353010.2 NP_001339939.1 S phase cyclin A-associated protein in the endoplasmic reticulum isoform d
NM_001353011.2 NP_001339940.1 S phase cyclin A-associated protein in the endoplasmic reticulum isoform e
NM_001353012.2 NP_001339941.1 S phase cyclin A-associated protein in the endoplasmic reticulum isoform d
NM_020843.4 NP_065894.2 S phase cyclin A-associated protein in the endoplasmic reticulum isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17698606 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
28794130 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAPER Protein Structure

zf-met

zf-met: Zinc-finger of C2H2 type (793 - 816)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1400 a.a.
Protein Preferred Names Protein Names

S phase cyclin A-associated protein in the endoplasmic reticulum

  • zinc finger protein 291

SCAPER Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCAPER Q9BY12 CDK2 Homo sapiens P24941
Anti Tag CoIP
17698606
Intra
SCAPER Q9BY12 CDK2 Homo sapiens P24941
Anti Bait CoIP
17698606
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Intellectual Developmental Disorder And Retinitis Pigmentosa

  • IDDRP
Speech Disorder

  • Speech Disorders
Brachydactyly
Syndromic Rod-Cone Dystrophy

  • Syndromic Retinitis Pigmentosa
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Late-Onset Retinal Degeneration

  • LORD

  • Retinal Degeneration, Late-Onset, Autosomal Dominant

  • Autosomal Dominant Late-Onset Retinal Degeneration

  • Pigmentary Retinopathy

  • Retinal Degeneration, Late-Onset

  • Retinitis Pigmentosa
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Combined Oxidative Phosphorylation Deficiency 16

  • COXPD16

  • Infantile Hypertrophic Cardiomyopathy Due To Mrpl44 Deficiency

  • Combined Oxidative Phosphorylation Defect Type 16

  • Combined Oxidative Phosphorylation Deficiency, Type 16
Cardiomyopathy, Dilated, 1l

  • Dilated Cardiomyopathy 1l

  • CMD1L

  • Cardiomyopathy, Dilated 1l

  • Cardiomyopathy, Dilated, Type 1l
Blount'S Disease

  • Blount Disease

  • Tibia Vara

  • Osteochondrosis Deformans Tibiae

  • Osteochondrosis Deformans Tibiae, Familial Infantile Type

  • Familial Infantile Type Osteochondrosis Deformans Tibiae

  • Blount-Barber Syndrome

  • Erlacher-Blount Syndrome

  • Infantile Tibia Vara

  • Tibia Vara Blount

  • Blount Disease, Infantile
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12485 SCAPER Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SCAPER VGNC VGNC:34321
Felis catus SCAPER VGNC VGNC:64899
Canis familiaris SCAPER VGNC VGNC:45895
Rattus norvegicus SCAPER RGD RGD:621585
Macaca mulatta SCAPER VGNC VGNC:77006
Mus musculus SCAPER MGD MGI:1925976
Others SCAPER NCBI