SPA17 - sperm autoantigenic protein 17 Gene

Also Known as CT22; SP17; SP17-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53340

About SPA17

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:124,673,904-124,697,518 (from NCBI)

This gene has 4 transcripts (splice variants), 148 orthologues and 2 paralogues. Biased expression in testis (RPKM 85.4), thyroid (RPKM 7.4) and 2 other tissues.

Summary

This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]

SPA17 Products (1)

mRNA Protein Name
NM_017425.4 NP_059121.1 sperm surface protein Sp17

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15257753 GOA
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
18421703 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18421703 GOA
located in motile cilium IDA
IDA: Inferred from direct assay
18421703 GOA
located in sperm fibrous sheath IDA
IDA: Inferred from direct assay
19604394 GOA
located in sperm principal piece IDA
IDA: Inferred from direct assay
15257753 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPA17 Protein Structure

RIIa

RIIa: Regulatory subunit of type II PKA R-subunit (14 - 51)

IQ

IQ: IQ calmodulin-binding motif (117 - 133)

  • 0
  • 100
  • 151 a.a.
Protein Preferred Names Protein Names

sperm surface protein Sp17

  • cancer/testis antigen 22

SPA17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SPA17 Q15506 AKAP7 Homo sapiens O43687-2
Y2H Prey Pooling
25416956
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Y2H Array
25416956
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Y2H Array
32296183
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
MAPPIT
25416956
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Y2H
17551920
Intra
SPA17 Q15506 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
32296183
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Anti Tag CoIP
28514442
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Y2H Prey Pooling
25416956
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Y2H Prey Pooling
32296183
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Y2H Array
32296183
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Y2H Array
25416956
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Anti Tag CoIP
33961781
Intra
SPA17 Q15506 MYL6B Homo sapiens P14649
Validated Y2H
25416956
Intra
SPA17 Q15506 ROPN1L Homo sapiens Q96C74
Y2H Prey Pooling
32296183
Intra
SPA17 Q15506 ROPN1L Homo sapiens Q96C74
Validated Y2H
32296183
Intra
SPA17 Q15506 ROPN1L Homo sapiens Q96C74
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPA17 Proteins

Cat. No. Product Name Accession Purity
HY-P701069 SP-17 Protein, Human (His) Q15506 (M1-K151) ≥ 95%, as determined by reducing SDS-PAGE.

SPA17 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84590 SP17 Antibody (YA4287) IHC-P, FC, ELISA Human
HY-P84590A SP17 Antibody (YA4287)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Testicular Cancer

  • Testis Cancer

  • Testicular Carcinoma

  • Testicular Neoplasms

  • Malignant Neoplasm Of Testis

  • Childhood Neoplasm Of The Testis

  • Neoplasm Of Testis

  • Pediatric Testicular Neoplasm

  • Testicular Tumor

  • Testis Neoplasm

  • Testicular Tumors

  • Testicular Neoplasm

  • Testicular Malignant Germ Cell Tumor

  • Childhood Testicular Neoplasm

  • Carcinoma Of The Testis

  • Cancer Of Testis

  • Malignant Neoplasm Of Testis, Nos

  • Malignant Neoplasm Of Testis, Unspecified

  • Malignant Tumour Of Testis

  • Testicle Cancer

  • Primary Malignant Neoplasm Of Testis
Pelvic Varices

  • Varix Of Pelvis

  • Pelvic Varicose Vein
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13613 SPA17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21050 Spa17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27568 Spa17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SPA17 RGD RGD:620154
Canis familiaris SPA17 VGNC VGNC:46691
Felis catus SPA17 VGNC VGNC:81934
Macaca mulatta SPA17 VGNC VGNC:77848
Bos taurus SPA17 VGNC VGNC:35160
Mus musculus SPA17 MGD MGI:1333778
Others SPA17 NCBI