Asb2 - ankyrin repeat and SOCS box-containing 2 Gene

Also Known as 1110008E15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 65256

Summary

Contributes to ubiquitin protein Ligase activity. Involved in several processes, including heart development; podosome assembly; and skeletal muscle atrophy. Acts upstream of or within cellular protein metabolic process; myoblast differentiation; and skeletal muscle cell differentiation. Located in Z disc. Part of Cul5-RING ubiquitin Ligase complex. Is expressed in several structures, including embryo mesenchyme; genitourinary system; gut; heart; and musculature. Orthologous to human ASB2 (ankyrin repeat and SOCS box containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Asb2 Products (2)

mRNA Protein Name
NM_001374764.1 NP_001361693.1 ankyrin repeat and SOCS box protein 2 isoform 2
NM_023049.1 NP_075536.1 ankyrin repeat and SOCS box protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26343497 MGI
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
29374072 MGI
involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
29374072 MGI
involved in dendritic cell migration IDA
IDA: Inferred from direct assay
23632887 MGI
involved in heart looping IMP
IMP: Inferred from mutant phenotype
32179481 MGI
involved in podosome assembly IMP
IMP: Inferred from mutant phenotype
23632887 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
23632887 MGI
involved in skeletal muscle atrophy IMP
IMP: Inferred from mutant phenotype
27182554 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
22147266 MGI
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
26343497 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
26343497 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ankyrin repeat and SOCS box protein 2

  • ASB-2

  • ankyrin repeat and SOCS box-containing protein 2

  • ankyrin repeat-containing SOCS box protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-172399 FTO-IN-14 / Unkown
HY-179267 FTO-IN-16 / Unkown
HY-RS01067 ASB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22107 Asb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28628 Asb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Asb2 NCBI NCBI:51676