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ASB2 - ankyrin repeat and SOCS box containing 2 Gene

Also Known as ASB-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51676

About ASB2

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:93,934,166-93,976,570 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 211 orthologues and 2 paralogues. Biased expression in heart (RPKM 15.5), prostate (RPKM 8.6) and 12 other tissues.

Summary

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin Ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASB2 Products (2)

mRNA	Protein	Name
NM_001202429.2	NP_001189358.1	ankyrin repeat and SOCS box protein 2 isoform 1
NM_016150.5	NP_057234.2	ankyrin repeat and SOCS box protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cullin family protein binding	IPI IPI: Inferred from physical interaction	21119685	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16325183	GOA
contributes to ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	16325183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	32179481	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	21119685	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16325183	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24044920	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16325183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB2 Protein Structure

Ank_4

Ank_2

Ank

Ank_2

SOCS_box

0
100
200
300
400
500
587 a.a.

Protein Preferred Names	Protein Names
ankyrin repeat and SOCS box protein 2	ankyrin repeat and SOCS box-containing protein 2a

Related Diseases

Diseases	Alias
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-172399	FTO-IN-14		/	Unkown
HY-179267	FTO-IN-16		/	Unkown
HY-RS01067	ASB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22107	Asb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28628	Asb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ASB2	VGNC	VGNC:59960
Canis familiaris	ASB2	VGNC	VGNC:38163
Macaca mulatta	ASB2	VGNC	VGNC:69840
Bos taurus	ASB2	VGNC	VGNC:26196
Mus musculus	ASB2	MGD	MGI:1929743
Rattus norvegicus	ASB2	RGD	RGD:1306414
Others	ASB2	NCBI