FOXRED2 - FAD dependent oxidoreductase domain containing 2 Gene

Also Known as ERFAD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80020

About FOXRED2

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,487,190-36,507,040 (from NCBI)

This gene has 18 transcripts (splice variants), 212 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 9.7), ovary (RPKM 6.3) and 24 other tissues.

Summary

Enables flavin adenine dinucleotide binding activity. Involved in ubiquitin-dependent ERAD pathway. Located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022]

FOXRED2 Products (4)

mRNA Protein Name
NM_001102371.2 NP_001095841.1 FAD-dependent oxidoreductase domain-containing protein 2 isoform 1 precursor
NM_001363041.2 NP_001349970.1 FAD-dependent oxidoreductase domain-containing protein 2 isoform 2 precursor
NM_001363042.2 NP_001349971.1 FAD-dependent oxidoreductase domain-containing protein 2 isoform 2 precursor
NM_024955.6 NP_079231.4 FAD-dependent oxidoreductase domain-containing protein 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
19706418 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19706418 GOA
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
19706418 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
19706418 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXRED2 Protein Structure

Pyr_redox_3

Pyr_redox_3: Pyridine nucleotide-disulphide oxidoreductase (34 - 249)

  • 0
  • 200
  • 400
  • 600
  • 684 a.a.
Protein Preferred Names Protein Names

FAD-dependent oxidoreductase domain-containing protein 2

  • ER flavoprotein associated with degradation

FOXRED2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FOXRED2 Q8IWF2 DNAJC10 Homo sapiens Q8IXB1
Anti Bait CoIP
19706418
Intra
FOXRED2 Q8IWF2 SEL1L Homo sapiens Q9UBV2
Pull Down
22119785
Intra
FOXRED2 Q8IWF2 SEL1L Homo sapiens Q9UBV2
Anti Tag CoIP
33961781
Intra
FOXRED2 Q8IWF2 SEL1L Homo sapiens Q9UBV2
Anti Tag CoIP
28514442
Intra
FOXRED2 Q8IWF2 SEL1L Homo sapiens Q9UBV2
Anti Tag CoIP
19706418
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05081 FOXRED2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FOXRED2 VGNC VGNC:40972
Bos taurus FOXRED2 VGNC VGNC:29107
Rattus norvegicus FOXRED2 RGD RGD:1306763
Felis catus FOXRED2 VGNC VGNC:62349
Macaca mulatta FOXRED2 VGNC VGNC:84769
Mus musculus FOXRED2 MGD MGI:106315
Others FOXRED2 NCBI