STX16 - syntaxin 16 Gene

Also Known as SYN16; SYN-16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8675

About STX16

Cytogenetic location: 20q13.32 Genomic coordinates (GRCh38): 20:58,651,283-58,679,526 (from NCBI)

This gene has 20 transcripts (splice variants), 202 orthologues, 12 paralogues and is associated with 2 phenotypes. Ubiquitous expression in spleen (RPKM 25.9), lymph node (RPKM 25.7) and 25 other tissues.

Summary

This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]

STX16 Products (5)

mRNA	Protein	Name
NM_001001433.3	NP_001001433.1	syntaxin-16 isoform a
NM_001134772.3	NP_001128244.1	syntaxin-16 isoform c
NM_001134773.3	NP_001128245.1	syntaxin-16 isoform d
NM_001204868.2	NP_001191797.1	syntaxin-16 isoform e
NM_003763.6	NP_003754.2	syntaxin-16 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SNAP receptor activity	IDA IDA: Inferred from direct assay	15215310	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18195106	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	16154903	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	23677696	GOA
involved in retrograde transport, endosome to Golgi	IDA IDA: Inferred from direct assay	15215310	GOA
involved in retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	17389686	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	9464276	GOA
located in Golgi cisterna	IDA IDA: Inferred from direct assay	17389686	GOA
part of SNARE complex	IDA IDA: Inferred from direct assay	19620288	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9587053	GOA
located in cytosol	IDA IDA: Inferred from direct assay	9587053	GOA
colocalizes with endoplasmic reticulum	IDA IDA: Inferred from direct assay	9587053	GOA
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	9587053	GOA
located in membrane	IDA IDA: Inferred from direct assay	9587053	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16154903	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	16154903	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX16 Protein Structure

Syntaxin

SNARE

0
100
200
300
325 a.a.

Protein Preferred Names	Protein Names
syntaxin-16

STX16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STX16	O14662	VAMP5	Homo sapiens	O95183	Validated Y2H	25416956
Intra	STX16	O14662	VAMP5	Homo sapiens	O95183	Y2H Prey Pooling	25416956
Intra	STX16	O14662	VPS45	Homo sapiens	Q9NRW7	Anti Tag CoIP	35271311
Intra	STX16	O14662	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	STX16	O14662	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

STX16 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82374	Syntaxin 16 Antibody (YA2119)	WB	Human, Mouse, Rat
HY-P82374A	Syntaxin 16 Antibody (YA2119)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pseudohypoparathyroidism, Type Ib	Pseudohypoparathyroidism Type 1b PHP1B Pseudohypoparathyroidism Ib Pseudohypoparathyroidism Type Ib Php Ib Pseudohypoparathyroidism 1b
Pseudohypoparathyroidism	Familial Pseudohypoparathyroidism Parathyroid Hormone Resistant Hypoparathyroidism Php - [Pseudohypoparathyroidism] Constitutional Chronic Hypocalcaemia
Pseudohypoparathyroidism, Type Ia	Albright'S Hereditary Osteodystrophy Albright Hereditary Osteodystrophy Pseudohypoparathyroidism Type 1a PHP1A Albright Hereditary Osteodystrophy With Multiple Hormone Resistance Pseudohypoparathyroidism Ia AHO Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy Pseudo-Pseudohypoparathyroidism Pseudohypoparathyroidism Type I A Php Ia Pseudopseudohypoparathyroidism Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Pphp Pseudopseudo-Hypoparathyroidism Aho-Php Syndrome Ia Albright Hereditary Osteodystrophy-Php Syndrome Ia Pseudohypoparathyroidism 1a Pseudohypoparathyroidism
Pseudopseudohypoparathyroidism	PPHP Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance Normocalcemic Pseudohypoparathyroidism Aho-Pphp Syndrome Albright Hereditary Osteodystrophy-Pphp Syndrome Pseudohypoparathyroidism
Hypothyroidism, Congenital, Nongoitrous, 1	Tsh Resistance CHNG1 Hypothyroidism Due To Tsh Receptor Mutations Thyrotropin Resistance Thyroid-Stimulating Hormone Rtsh Hypothyroidism Due To Unresponsiveness To Thyrotropin Congenital Nongoitrous Hypothyroidism 1 Thyroid-Stimulating Hormone, Resistance To Hypothyroidism, Nonautoimmune Hypothyroidism, Congenital, Due To Tsh Resistance Hypothyroidism, Congenital, Non-Goitrous, 1 Congenital Hypothyroidism Due To Tsh Resistance Non-Autoimmune Hypothyroidism Thyroid-Stimulating Hormone Resistance Hypothyroidism, Congenital, Nongoitrous, Type 1 Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome
Hyperphosphatemia
Severe Congenital Neutropenia 5	Congenital Neutropenia-Myelofibrosis-Nephromegaly Syndrome Congenital Neutropenia-Bone Marrow Fibrosis-Nephromegaly Syndrome Vps45 Deficiency Scn5
Eiken Syndrome	Eiken Skeletal Dysplasia Bone Modeling Defect Of Hands And Feet EKNS
Pontocerebellar Hypoplasia, Type 2e	Pontocerebellar Hypoplasia Type 2 Pontocerebellar Hypoplasia Type 2e Pch2 PCH2E Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy Pontocerebellar Hypoplasia 2e Pcca2 Progressive Cerebello-Cerebral Atrophy Type 2 Doid:0112328 Hypoplasia, Pontocerebellar, Type 2e Pontocerebellar Hypoplasia, Type 2d Pontocerebellar Hypoplasia Type 2a
Amyotrophic Lateral Sclerosis, Juvenile, With Dementia	Juvenile Amyotrophic Lateral Sclerosis With Dementia Als-Dementia Complex
Acrodysostosis	Acrodysplasia Arkless-Graham Syndrome Maroteaux-Malamut Syndrome Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Osseous Heteroplasia, Progressive	Progressive Osseous Heteroplasia POH Osteoma Cutis Familial Ectopic Ossification Ectopic Ossification Familial Type Ectopic Ossification Heterotopic Ossification Ectopic Ossification, Familial Cutaneous Ossification Myositis Ossificans Progressiva Osteodermia Osteosis Cutis Ossification Heterotopic Heteroplasia, Osseous, Progressive Fibrodysplasia Ossificans Progressiva
Metal Metabolism Disorder	Metal Metabolism, Inborn Errors Inborn Metal Metabolism Disorder
Phosphorus Metabolism Disease	Phosphorus Metabolism Disorders Disorder Of Phosphorus Metabolism Phosphorus Disorder Phosphorus Metabolism Disorder
Human Granulocytic Anaplasmosis	Human Granulocytic Ehrlichiosis Hge Human Ehrlichial Infection, Human Granulocytic Type Human Anaplasmosis Due To Anaplasma Phagocytophilum
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Brachydactyly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13977	STX16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	STX16	RGD	RGD:1309423
Bos taurus	STX16	VGNC	VGNC:110067
Mus musculus	STX16	MGD	MGI:1923396
Felis catus	STX16	VGNC	VGNC:110159
Canis familiaris	STX16	VGNC	VGNC:110099
Others	STX16	NCBI