2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Endogenous Metabolite Cannabinoid Receptor
  4. Virodhamine

Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases.

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Virodhamine Chemical Structure

Virodhamine Chemical Structure

CAS No. : 287937-12-6

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Based on 1 publication(s) in Google Scholar

Virodhamine Related Antibodies

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Description

Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases[1][2].

In Vitro

Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus[1].
Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1[1].
Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control[1].
Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Virodhamine Related Antibodies

RT-PCR[1]

Cell Line: Megakaryocyte cell line
Concentration: 10, 20 and 40 μM
Incubation Time: 72 h
Result: Dose‐dependently enhanced the expression level of megakaryocytic marker CD61 and the expression of TRPV1 mRNA.
In Vivo

Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety[2]
Dosage: 1, 5 and 10 mg/kg
Administration: Intraperitoneal injection; 1-10 mg/kg; once
Result: Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.
Molecular Weight

347.53

Formula

C22H37NO2
CAS No.
Appearance

Viscous Liquid

Color

Yellow to brown

SMILES

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(OCCN)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (287.74 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8774 mL 14.3872 mL 28.7745 mL
5 mM 0.5755 mL 2.8774 mL 5.7549 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8774 mL 14.3872 mL 28.7745 mL 71.9362 mL
5 mM 0.5755 mL 2.8774 mL 5.7549 mL 14.3872 mL
10 mM 0.2877 mL 1.4387 mL 2.8774 mL 7.1936 mL
15 mM 0.1918 mL 0.9591 mL 1.9183 mL 4.7957 mL
20 mM 0.1439 mL 0.7194 mL 1.4387 mL 3.5968 mL
25 mM 0.1151 mL 0.5755 mL 1.1510 mL 2.8774 mL
30 mM 0.0959 mL 0.4796 mL 0.9591 mL 2.3979 mL
40 mM 0.0719 mL 0.3597 mL 0.7194 mL 1.7984 mL
50 mM 0.0575 mL 0.2877 mL 0.5755 mL 1.4387 mL
60 mM 0.0480 mL 0.2398 mL 0.4796 mL 1.1989 mL
80 mM 0.0360 mL 0.1798 mL 0.3597 mL 0.8992 mL
100 mM 0.0288 mL 0.1439 mL 0.2877 mL 0.7194 mL
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Virodhamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Virodhamine287937-12-6Endogenous MetaboliteCannabinoid ReceptorendocannabinoiMAPKROSmegakaryocytic differentiationneurological disorderAlzheimer's disease Parkinson's diseaseInhibitorinhibitorinhibit

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