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264W94 

Cat. No.: HY-19264
Handling Instructions

264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action.

For research use only. We do not sell to patients.

264W94 Chemical Structure

264W94 Chemical Structure

CAS No. : 178961-24-5

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Description

264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action[1].

IC50 & Target

IBAT[1]

In Vitro

264W94 (0, 0.1, 0.25, 0.5 μM) inhibits human IBAT-specific transport of 5 μM TC by 14% to 75% in a concentration-dependent manner with IC50 of 0.25 μM in CHO-hIBAT cells[1].

In Vivo

264W94 (orally; 0.03-1.0 mg/kg; twice a day for 3.5 days) dose-dependently attenuates diet-induced increases in serum LDL+VLDL-C, as well as the decrease in HDL-C[1].
264W94 (orally; 0.003, 0.01, 0.03, 0.1 mg/kg; twice a day for 2 days) increases fecal excretion of 75SeHCAT in a dose-dependent manner[1].
264W94 (0.001, 0.01, 0.1, 1, and 10 mg/kg; twice a day for 2 weeks) reduces dose-dependently plasma glucose in male ZDF (ZDF/GmiCrl-fa/fa) rats. Treatment of 264W94 prevents the decline of insulin dose-dependently without an increase in proinsulin levels[2].

Animal Model: Male Sprague Dawley rats (CD, Charles River, 270-310 gm)[1]
Dosage: 0.03, 0.1, 0.3, 1.0 mg/kg
Administration: Orally; twice a day (9:00 am and 3:30 pm) for 3.5 days
Result: Dose-dependently attenuated diet-induced increases in serum LDL+VLDL-C, as well as the decrease in HDL-C.
Molecular Weight

417.56

Formula

C₂₃H₃₁NO₄S

CAS No.

178961-24-5

SMILES

COC1=C(OC)C=C(C2=C1)[[email protected]@H](C3=CC=CC=C3)N[[email protected]](CC)(CCCC)CS2(=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

264W94OthersInhibitorinhibitorinhibit

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264W94
Cat. No.:
HY-19264
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