2. Immunology/Inflammation
  3. Thrombopoietin Receptor
  4. AH23848

AH23848 (compound 6) is a competitive blocker of the thromboxane A2 receptor and an orally effective agent, with an IC50 value of 50 nM against human targets and a long duration of action.

For research use only. We do not sell to patients.

AH23848

AH23848 Chemical Structure

CAS No. : 81443-73-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of AH23848:

Other Forms of AH23848:

AH23848 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE AH23848

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AH23848 (compound 6) is a competitive blocker of the thromboxane A2 receptor and an orally effective agent, with an IC50 value of 50 nM against human targets and a long duration of action. AH23848 shows no activity against other prostaglandin, serotonin (5-HT) or adenosine diphosphate (ADP) receptors. AH23848 can be used in the research of occlusive vascular diseases[1]. In Vitro:AH23848 (compound 6) (3.0×10-8-3.0×10-6 mol/liter; 30 min) acts as a competitive antagonist of thromboxane A2 receptors in isolated human pulmonary artery smooth muscle with a pA2 of 7.8[1].
AH23848 (6.0×10-8-6.0×10-6 mol/liter; 1.0×10-5 mol/liter) competitively antagonizes thromboxane A2 receptors in isolated rat aorta smooth muscle with a pA2 of 7.94, and does not block 5-HT or potassium chloride-induced contractions at concentrations up to 1.0×10-5 mol/liter[1].
AH23848 (1.0×10−6 mol/liter) does not block PGE2- or PGF2α-induced contractions in isolated non-vascular smooth muscle preparations[1].
AH23848 (1.0×10-7-1.0×10-4 mol/liter) potently and specifically inhibits thromboxane receptor-dependent platelet aggregation in human platelet-rich plasma, with IC50 values ranging from 1.05×10-7 to 6.3×10-7 mol/liter for different agonists, and does not block ADP-, 5-HT-, or epinephrine-induced aggregation[1]. In Vivo:AH23848 (0.03-1.0 mg/kg; i.v.; single bolus) potently and specifically inhibits collagen-induced thromboembolic and bronchoconstrictor responses in anesthetized guinea pigs, with no effect on ADP-induced thrombocytopenia at doses up to 1.0 mg/kg i.v[1].
AH23848 (0.01-0.3 mg/kg; i.v.; single bolus) specifically antagonizes U-46619-induced mesenteric vasoconstriction in anesthetized Beagle dogs without altering baseline hemodynamic parameters, with a 6.5-fold rightward shift of the U-46619 dose-response curve at 0.1 mg/kg i.v[1].
AH23848 (1 mg/kg; p.o.; single dose) produces sustained, specific inhibition of collagen-induced platelet aggregation in conscious Beagle dogs, with peak effects showing a 23-fold rightward shift of the collagen dose-response curve and residual activity lasting at least 11 hours[1].

In Vivo
Animal Model: Guinea pig (anesthetized)[1]
Dosage: 0.03 mg/kg (collagen-induced responses); 1.0 mg/kg (ADP-induced thrombocytopenia)
Administration: i.v.; single bolus
Result: Substantially reduced collagen-induced thrombocytopenia.
Almost completely abolished the collagen-induced diastolic pressor response.
Nearly eliminated collagen-induced bronchoconstriction.
Showed no inhibitory effect on ADP-induced thrombocytopenia at 1.0 mg/kg.
Animal Model: Beagle dog (anesthetized)[1]
Dosage: 0.01-0.3 mg/kg
Administration: i.v.; single bolus
Result: Had little or no effect on baseline blood pressure or mesenteric arterial blood flow.
Specifically antagonized U-46619-induced mesenteric vasoconstriction.
Produced a mean 6.5-fold rightward shift in the U-46619 dose-effect curve at 0.1 mg/kg.
Animal Model: Beagle dog (conscious)[1]
Dosage: 1 mg/kg
Administration: p.o.; single dose
Result: Produced a marked inhibition of collagen-induced platelet aggregation ex vivo, with a mean peak 23-fold rightward shift of the collagen concentration-aggregation curve.
Showed a residual twofold rightward shift still evident 11 hours after dosing.
Had no inhibitory effect on ADP-induced platelet aggregation ex vivo.
Molecular Weight

477.60

Formula

C29H35NO5
CAS No.
SMILES

C(C/C=C\CCC(O)=O)[C@H]1[C@@H](C(=O)C[C@H]1OCC2=CC=C(C=C2)C3=CC=CC=C3)N4CCOCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AH23848 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AH2384881443-73-4AH 23848AH-23848Thrombopoietin Receptorhuman pulmonary artery smooth muscle5-HT receptorsrat aorta smooth muscleocclusive vascular diseaseguinea pigsthromboxane A2 receptordog saphenous vein smooth muscleprostanoid receptorshuman plateletsADP receptorsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AH23848
Cat. No.:
HY-10419
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.