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E-​6123 

Cat. No.: HY-10164
Handling Instructions

E-​6123 is a platelet-activating factor (PAF) receptor antagonist.

For research use only. We do not sell to patients.

E-​6123 Chemical Structure

E-​6123 Chemical Structure

CAS No. : 131614-02-3

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

E-​6123 is a platelet-activating factor (PAF) receptor antagonist.

IC50 & Target

PAF[1]

In Vitro

E-6123 (E6123) partially inhibits the Thapsigargin-induced increase in the levels of interleukin-6 mRNA and interleukin-6 protein. To clarify the role of the concurrently produced cell-associated PAF in the thapsigargin-induced increase in the interleukin-6 mRNA level and interleukin-6 production, the effects of the PAF receptor antagonist E-6123 are examined. E-6123 at 1 and 10 μM partially inhibits the Thapsigargin (46.1 nM)-induced increase in the interleukin-6 mRNA level at 4 h and interleukin-6 production at 8 h[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2125 mL 11.0627 mL 22.1254 mL
5 mM 0.4425 mL 2.2125 mL 4.4251 mL
10 mM 0.2213 mL 1.1063 mL 2.2125 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

The viability of the cells is examined in each set of experiments by a procedure using MTT, which is based on the ability of mitochondrial succinate dehydrogenase to cleave MTT to the blue compound formazan. After the peritoneal cells are incubated for the periods indicated in 10 mL of medium containing the various drugs (e.g., E-6123), 1 mL of MTT solution in phosphate-buffered saline (5 mg/mL, pH 7.4) is added to each dish, and the cells are further incubated for 4 h at 37 °C. Next, 2.5 mL of 0.04 N HCl solution in isopropanol is added, and the cells are sonicated at 10% maximum power for 3 s. The resultant colored product is read on a Microplate Reader at 570 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

451.97

Formula

C₂₃H₂₂ClN₅OS

CAS No.

131614-02-3

SMILES

O=C(C1CC1)N2CC3=C(CC2)C(C(C4=CC=CC=C4Cl)=N[[email protected]]5C)=C(S3)N6C5=NN=C6C

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
E-​6123
Cat. No.:
HY-10164
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E-​6123

Cat. No.: HY-10164