1. Protein Tyrosine Kinase/RTK
  2. FGFR
  3. FGFR4-IN-1

FGFR4-IN-1 

Cat. No.: HY-100631 Purity: 99.88%
Handling Instructions

FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.

For research use only. We do not sell to patients.

FGFR4-IN-1 Chemical Structure

FGFR4-IN-1 Chemical Structure

CAS No. : 1708971-72-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 130 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 230 In-stock
Estimated Time of Arrival: December 31
50 mg USD 700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 990 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

FGFR4-IN-1 is a potent inhibiotr of FGFR4 with IC50 of 0.7 nM.

IC50 & Target[1]

FGFR4

0.7 nM (IC50)

In Vitro

FGFR4-IN-1 significantly inhibits the proliferation of HuH-7 hepatocellular carcinoma cells with IC50 of 7.8 nM[1].

Molecular Weight

493.52

Formula

C₂₄H₂₇N₇O₅

CAS No.

1708971-72-5

SMILES

O=C(N1CCCC2=C1N=C(C=O)C(CN3C(COCC3)=O)=C2)NC4=NC=C(C#N)C(NCCOC)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6.4 mg/mL (12.97 mM; Need warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0263 mL 10.1313 mL 20.2626 mL
5 mM 0.4053 mL 2.0263 mL 4.0525 mL
10 mM 0.2026 mL 1.0131 mL 2.0263 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

Methylene blue staining proliferation assay (MBS): The effect of compounds on cell proliferation is assessed using HuH-7 hepatocellular carcinoma cells are cultured in the vendor-recommended medium. Specifically, 5000 cells/well are seeded in 96-well tissue culture plates in a total media volume of 100 μL/well and increasing compound dilutions or DMSO are added 24 hours thereafter in triplicates. 72 hours after compound addition, cells are fixed by adding 25 and incubated for 10 minutes at room temperature. Cells are washed three times with H2O. Cells are washed 3 times with H2O, 200 mL/well and then lysed by adding 200 mL/well of 3% HCl for 30 minutes at room temperature with shaking. Optical density is measured at A650 nm. The concentration of compound providing 50% of proliferation inhibition with respect to DMSO-treated cells is determined (IC50) using XLFit software.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

FGFR4-IN-1FGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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FGFR4-IN-1
Cat. No.:
HY-100631
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