1. Metabolic Enzyme/Protease
  2. HIV Protease
  3. L-689502

L-689502 

Cat. No.: HY-U00261
Handling Instructions

L-689502 is a potent inhibitor of HIV-l protease with an IC50 of 1 nM.

For research use only. We do not sell to patients.

L-689502 Chemical Structure

L-689502 Chemical Structure

CAS No. : 138483-63-3

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Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

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Description

L-689502 is a potent inhibitor of HIV-l protease with an IC50 of 1 nM.

IC50 & Target

IC50: 1 nM (HIV-l protease)[1]

In Vitro

Both L694746 and L-689502 inhibit HIV-l ptotease activity in a concentration-dependent manner. Pepstatin is much less potent than either compound exhibiting an IC50 of 2 μM. L694746 is as potent as L-689502 in inhibiting the HIV-l protease despite being structurally different from L-689502[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[1]

G689502 (3.3 pmoles in 1 mL of 100% DMSO) is added to cultures that have been growing for 48 hr. The final substrate and DMSO concentrations during the fermentation period are 65 pM and 2%, respectively. The fermentations containing L-689502 are carried out for an additional 72-96 hr prior to be harvested.The whole broth is sequenthdly extracted with methanol (0.5 vol) and acetone (0.5 vol). The supematant containing the derivatives of L-689502 is separated from the mycelia by filtration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

673.84

Formula

C₃₉H₅₁N₃O₇

CAS No.

138483-63-3

SMILES

O=C(OC(C)(C)C)N[[email protected]@H](CC1=CC=CC=C1)[[email protected]@H](O)C[[email protected]@H](CC2=CC=C(OCCN3CCOCC3)C=C2)C(N[[email protected]@H]4[[email protected]](O)CC5=C4C=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
L-689502
Cat. No.:
HY-U00261
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L-689502

Cat. No.: HY-U00261