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Manitimus (Synonyms: FK778)

Cat. No.: HY-101603 Purity: 99.57%
Handling Instructions

Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive drug.

For research use only. We do not sell to patients.

Manitimus Chemical Structure

Manitimus Chemical Structure

CAS No. : 202057-76-9

Size Price Stock Quantity
1 mg USD 240 In-stock
Estimated Time of Arrival: December 31
5 mg USD 480 In-stock
Estimated Time of Arrival: December 31
10 mg USD 816 In-stock
Estimated Time of Arrival: December 31
20 mg USD 1440 In-stock
Estimated Time of Arrival: December 31
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Description

Manitimus is an inhibitor of dehydroorotate dehydrogenase, and a potent immunosuppressive drug.

In Vivo

In the Manitimus-treated rats, there is a dose-related, differential effect: mean survival is 15.7 days in group 4 (Manitimus 5 mg/kg), 19.1 days in group 5 (Manitimus 10 mg/kg) and 25.4 days in group 6 (Manitimus 20 mg/kg)[1]. Manitimus (15 mg/kg, p.o.) results in a significant decrease in neointimal area and percentage of stenosis versus the control rats, and diminishes the effect that CMV infection results in a significant increase in intimal and medial cross-sectional area and medial wall thickness of the vein grafts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

308.26

Formula

C₁₅H₁₁F₃N₂O₂

CAS No.

202057-76-9

SMILES

C#CCC/C(O)=C(C#N)/C(NC1=CC=C(C(F)(F)F)C=C1)=O.[(Z)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (811.00 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2440 mL 16.2201 mL 32.4401 mL
5 mM 0.6488 mL 3.2440 mL 6.4880 mL
10 mM 0.3244 mL 1.6220 mL 3.2440 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (20.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (20.28 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[2]

The whole experiment consists of a total of four experimental groups (n = 10 animals/group) which all undergo surgery. Furthermore, rats are either infected with CMV, treated with Manitimus or both. A control group only receive the Manitimus solvent (1 mL of a 1% carboxymethylcellulose solution in water). Infection is established by inoculating rats intraperitoneally with 1.25×106 plaque-forming units of homogenized salivary gland-derived rat CMV immediately after surgery.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.57%

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Keywords:

ManitimusFK778FK 778FK-778OthersInhibitorinhibitorinhibit

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Manitimus
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