2. Signaling Pathways
  3. Epigenetics
  4. Histone Methyltransferase
  5. PRMT5 Isoform
  6. PRMT5 Inhibitor

PRMT5 Inhibitor

PRMT5 Inhibitors (14):

Cat. No. Product Name Effect Purity
  • HY-101564
    Onametostat
    		Inhibitor 99.79%
    Onametostat (JNJ-64619178) is a selective, orally active and pseudo-irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 0.14 nM.
  • HY-139611
    MRTX-1719
    		Inhibitor 99.28%
    MRTX-1719 is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAPDEL SDMA cells.
  • HY-128579
    DW14800
    		Inhibitor 99.63%
    DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM.
  • HY-131493
    PF-06939999
    		Inhibitor
    PF-06939999 (PRMT5-IN-3) is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents.
  • HY-139611C
    MRTX-1719 hydrochloride
    		Inhibitor 99.22%
    MRTX-1719 hydrochloride is a potent first-in-class selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAPDEL SDMA cells.
  • HY-146810
    PRMT4-IN-1
    		Inhibitor
    PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM).
  • HY-P3821
    PRMT5-IN-22
    		Inhibitor
    PRMT5-IN-22 (compound 53) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) with anti-tumor activity.
  • HY-141876
    PRMT5-IN-14
    		Inhibitor
    PRMT5-IN-14 is a PRMT5 inhibitor to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.
  • HY-149005
    PRMT5-IN-19
    		Inhibitor
    PRMT5-IN-19 (Compound 41) is an selective orally active non-nucleoside PRMT5 inhibitor with IC50 values of 23.9 nM (radioactive biochemical assay) and 47 nM (AlphaLISA assay).
  • HY-139611B
    (S)-MRTX-1719
    		Inhibitor
    (S)-MRTX-1719 (example 16-7) is the S-enantiomer of MRTX-1719.
  • HY-134883
    PRMT5-IN-4
    		Inhibitor
    PRMT5-IN-4 (compound AAA-1) is a PRMT5 inhibitor.
  • HY-132937
    PRMT5-IN-9
    		Inhibitor
    PRMT5-IN-9 is a novel PRMT5 inhibitor for researching cancer, with an IC50 of 0.01 μM.
  • HY-P3822
    PRMT5-IN-23
    		Inhibitor
    PRMT5-IN-23 (compound 50) is an inhibitor of protein arginine methyltransferase 5 (PRMT5) with anti-tumor activity.
  • HY-150081
    PRMT5-IN-21
    		Inhibitor
    PRMT5-IN-21 (compound 1) is a potent cyclonucleoside PRMT5 inhibitor.