PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Produits associés (4114)
Produits associés (4114)
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PROTAC Linkers Isoform Comparison
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4,4'-(Butane-1,4-diylbis(oxy))dianiline
0 ImagesCat. No.: HY-W107379CAS No.: 6245-50-7
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Mal-NH-PEG8-CH2CH2COOPFP ester
0 ImagesCat. No.: HY-130863CAS No.: 2055023-14-6
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6-(Methylamino)hexan-1-ol
0 ImagesCat. No.: HY-W554181CAS No.: 50347-17-6
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N1-Methylpentane-1,5-diamine
0 ImagesCat. No.: HY-W239318CAS No.: 32752-52-6
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rel-(3S,4S)-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid
0 ImagesCat. No.: HY-W036661CAS No.: 1903422-62-7
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Azide-PEG12-Tos
0 ImagesAzide-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG12-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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4-(Boc-NH-Me)-(trans)-Cyclohexane-OH
0 ImagesCat. No.: HY-W093719CAS No.: 1021919-45-8
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13-(Benzyloxy)-13-oxotridecanoic acid
0 ImagesCat. No.: HY-W130167CAS No.: 261178-55-6
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tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate hydrochloride
0 ImagesCat. No.: HY-W125143CAS No.: 193902-64-6
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Methanamine-PEG4-methanamine
0 ImagesCat. No.: HY-W795326CAS No.: 72236-27-2
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(S,R.S)-AHPC-PEG8-acid
0 ImagesCat. No.: HY-W190942CAS No.: 2428400-60-4
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Tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]propanoate
![Tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]propanoate](https://file.medchemexpress.com/product_pic/hy-w662859.gif "Click to View Tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]propanoate Product Detail")
0 ImagesCat. No.: HY-W662859CAS No.: 1802892-92-7
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1,4-bUtanedithiol
0 ImagesCat. No.: HY-W157316CAS No.: 1191-08-8
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tert-Butyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W244439CAS No.: 1258639-00-7
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P131
0 ImagesCat. No.: HY-W591307CAS No.: 2360561-66-4P131 is a PROTAC molecule comprised of Pomalidomide-based cereblon ligand and IBT6A, linked by a PEG 3 chain. P131 can degrade both wild-type and C481S mutant BTK with nanomolar potencies.
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4-((4-Aminopiperidin-1-yl)methyl)benzonitrile hydrochloride
0 ImagesCat. No.: HY-W104895CAS No.: 1353977-72-6
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Ts-PEG3-O-C-alkynes-TBS
0 ImagesCat. No.: HY-W836955CAS No.: 2742250-22-0
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7-Aminoheptanoic acid hydrochloride
0 ImagesCat. No.: HY-W002042ACAS No.: 62643-56-5
