2. PROTAC
  3. PROTAC Linkers
  4. P131

P131 is a PROTAC molecule comprised of Pomalidomide-based cereblon ligand and IBT6A, linked by a PEG 3 chain. P131 can degrade both wild-type and C481S mutant BTK with nanomolar potencies.

For research use only. We do not sell to patients.

P131

P131 Chemical Structure

CAS No. : 2360561-66-4

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P131 Related Antibodies

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Description

P131 is a PROTAC molecule comprised of Pomalidomide-based cereblon ligand and IBT6A, linked by a PEG 3 chain. P131 can degrade both wild-type and C481S mutant BTK with nanomolar potencies.

Cellular Effect
Cell Line Type Value Description References
HBL GI50
28 nM
Compound: 74
Antiproliferative activity against human HBL cells assessed as inhibition of cell growth
Antiproliferative activity against human HBL cells assessed as inhibition of cell growth
[PMID: 36324498]
HBL1 GI50
28 nM
Compound: 24; P13I
Antiproliferative activity against human HBL1 cells expressing BTK C481S mutant assessed as growth inhibition
Antiproliferative activity against human HBL1 cells expressing BTK C481S mutant assessed as growth inhibition
[PMID: 32698111]
HBL1 GI50
28 nM
Compound: 49; P131
Inhibition of cell proliferation in human HBL1 cells harboring Ibrutinib-resistant BTK C481S mutant assessed as cell growth inhibition
Inhibition of cell proliferation in human HBL1 cells harboring Ibrutinib-resistant BTK C481S mutant assessed as cell growth inhibition
[PMID: 35594541]
TMD8 IC50
15 nM
Compound: P13I
Cytotoxicity against human TMD8 cells incubated for 48 hrs by celltitre glo 2.0 assay
Cytotoxicity against human TMD8 cells incubated for 48 hrs by celltitre glo 2.0 assay
[PMID: 37195170]
Molecular Weight

912.95

Formula

C46H48N12O9
CAS No.
SMILES

NC1=NC=NC2=C1C(C3=CC=C(C=C3)OC4=CC=CC=C4)=NN2[C@@H]5CCCN(C5)C(C6=CN(N=N6)CCOCCOCCOCCNC7=C8C(N(C(C8=CC=C7)=O)C9CCC(NC9=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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P131 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P1312360561-66-4P 131P-131PROTAC LinkersInhibitorinhibitorinhibit

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HY-W591307
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