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Cat. No.: HY-W591307

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P131

P131 is a PROTAC molecule comprised of Pomalidomide-based cereblon ligand and IBT6A, linked by a PEG 3 chain. P131 can degrade both wild-type and C481S mutant BTK with nanomolar potencies.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2360561-66-4
화학식: C₄₆H₄₈N₁₂O₉
분자량:912.95

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (240 KB)

P131 Chemical Structure

CAS No.: 2360561-66-4

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Biological Activity
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Biological Activity

제품 설명

P131 is a PROTAC molecule comprised of Pomalidomide-based cereblon ligand and IBT6A, linked by a PEG 3 chain. P131 can degrade both wild-type and C481S mutant BTK with nanomolar potencies.

All PROTAC Linkers Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HBL	GI₅₀	28 nM Compound: 74	Antiproliferative activity against human HBL cells assessed as inhibition of cell growth Antiproliferative activity against human HBL cells assessed as inhibition of cell growth	[PMID: 36324498]
HBL1	GI₅₀	28 nM Compound: 24; P13I	Antiproliferative activity against human HBL1 cells expressing BTK C481S mutant assessed as growth inhibition Antiproliferative activity against human HBL1 cells expressing BTK C481S mutant assessed as growth inhibition	[PMID: 32698111]
HBL1	GI₅₀	28 nM Compound: 49; P131	Inhibition of cell proliferation in human HBL1 cells harboring Ibrutinib-resistant BTK C481S mutant assessed as cell growth inhibition Inhibition of cell proliferation in human HBL1 cells harboring Ibrutinib-resistant BTK C481S mutant assessed as cell growth inhibition	[PMID: 35594541]
TMD8	IC₅₀	15 nM Compound: P13I	Cytotoxicity against human TMD8 cells incubated for 48 hrs by celltitre glo 2.0 assay Cytotoxicity against human TMD8 cells incubated for 48 hrs by celltitre glo 2.0 assay	[PMID: 37195170]

Chemical Information

CAS No. 2360561-66-4
분자량 912.95
화학식 C₄₆H₄₈N₁₂O₉
SMILES

NC1=NC=NC2=C1C(C3=CC=C(C=C3)OC4=CC=CC=C4)=NN2[C@@H]5CCCN(C5)C(C6=CN(N=N6)CCOCCOCCOCCNC7=C8C(N(C(C8=CC=C7)=O)C9CCC(NC9=O)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.