PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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2-(Piperidin-4-yl)ethyl acetate hydrochloride
0 ImagesCat. No.: HY-W911809CAS No.: 184042-52-2
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Tert-butyl 3-oxo-4-(piperidin-4-yl)piperazine-1-carboxylate
0 ImagesCat. No.: HY-W345438CAS No.: 856418-53-6
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tert-Butyl 2-(2-iodoethoxy)acetate
0 ImagesCat. No.: HY-W442080CAS No.: 1401351-72-1
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Azido-PEG2-CH2COOH (Standard)
0 ImagesCat. No.: HY-108368RCAS No.: 882518-90-3Azido-PEG2-CH2COOH (Standard) is the analytical standard of Azido-PEG2-CH2COOH (HY-108368). This product is intended for research and analytical applications. Azido-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Azido-PEG2-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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tert-Butyl 7-(aminomethyl)-2-azaspiro[4.4]nonane-2-carboxylate
![tert-Butyl 7-(aminomethyl)-2-azaspiro[4.4]nonane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w067884.gif "Click to View tert-Butyl 7-(aminomethyl)-2-azaspiro[4.4]nonane-2-carboxylate Product Detail")
0 ImagesCat. No.: HY-W067884CAS No.: 1341036-75-6
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tert-Butyl (6-(2-chloroacetamido)hexyl)carbamate
0 ImagesCat. No.: HY-W107027CAS No.: 201282-04-4
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Ethyl 2-(2-iodoethoxy)acetate
0 ImagesCat. No.: HY-W399304CAS No.: 56703-25-4
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2-(6-Bromohexyloxy)tetrahydro-2H-pyran
0 ImagesCat. No.: HY-W128280CAS No.: 53963-10-3
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m-PEG5-Hydrazide
0 ImagesCat. No.: HY-135921CAS No.: 1449390-65-1
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4-((4-Iodobenzyl)oxy)piperidine hydrochloride
0 ImagesCat. No.: HY-W104867CAS No.: 1220034-88-7
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Tert-butyl (3-azaspiro[5.5]Undecan-9-yl)carbamate
![Tert-butyl (3-azaspiro[5.5]Undecan-9-yl)carbamate](https://file.medchemexpress.com/product_pic/hy-w392618.gif "Click to View Tert-butyl (3-azaspiro[5.5]Undecan-9-yl)carbamate Product Detail")
0 ImagesCat. No.: HY-W392618CAS No.: 1781848-83-6
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Dimethyl trans-1,4-cyclohexanedicarboxylate
0 ImagesCat. No.: HY-W057761CAS No.: 3399-22-2
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Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate
0 ImagesCat. No.: HY-W613030CAS No.: 1392140-97-4
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tert-Butyl (2-(2-(aminooxy)ethoxy)ethyl)carbamate
0 ImagesCat. No.: HY-W190869CAS No.: 1596369-00-4
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Methyl 3-iodopropiolate
0 ImagesCat. No.: HY-W251660CAS No.: 155004-90-3
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Cbz-azaspiro[3.3]heptane-OH
![Cbz-azaspiro[3.3]heptane-OH](https://file.medchemexpress.com/product_pic/hy-w057967.gif "Click to View Cbz-azaspiro[3.3]heptane-OH Product Detail")
0 ImagesCat. No.: HY-W057967CAS No.: 1363383-32-7
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1-(Piperidin-4-ylmethyl)piperidine
0 ImagesCat. No.: HY-W209253CAS No.: 32470-52-3
![tert-Butyl 7-(aminomethyl)-2-azaspiro[3.5]nonane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w063558.gif "Click to View tert-Butyl 7-(aminomethyl)-2-azaspiro[3.5]nonane-2-carboxylate Product Detail")
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2-(Piperidin-4-yl)-acetic acid ethyl ester
0 ImagesCat. No.: HY-W002927CAS No.: 59184-90-6
