1. PROTAC
  2. PROTAC Linkers
  3. Potassium succinate trihydrate

Potassium succinate trihydrate is a PROTAC linker that can be used in the synthesis of PROTACs.

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Potassium succinate trihydrate

Potassium succinate trihydrate Chemical Structure

CAS No. : 6100-18-1

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Description

Potassium succinate trihydrate is a PROTAC linker that can be used in the synthesis of PROTACs.

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E805 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

248.31

Formula

C4H10K2O7

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCC(O[K])=O)O[K].O.O.O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 200 mg/mL (805.44 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0272 mL 20.1361 mL 40.2722 mL
5 mM 0.8054 mL 4.0272 mL 8.0544 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0272 mL 20.1361 mL 40.2722 mL 100.6806 mL
5 mM 0.8054 mL 4.0272 mL 8.0544 mL 20.1361 mL
10 mM 0.4027 mL 2.0136 mL 4.0272 mL 10.0681 mL
15 mM 0.2685 mL 1.3424 mL 2.6848 mL 6.7120 mL
20 mM 0.2014 mL 1.0068 mL 2.0136 mL 5.0340 mL
25 mM 0.1611 mL 0.8054 mL 1.6109 mL 4.0272 mL
30 mM 0.1342 mL 0.6712 mL 1.3424 mL 3.3560 mL
40 mM 0.1007 mL 0.5034 mL 1.0068 mL 2.5170 mL
50 mM 0.0805 mL 0.4027 mL 0.8054 mL 2.0136 mL
60 mM 0.0671 mL 0.3356 mL 0.6712 mL 1.6780 mL
80 mM 0.0503 mL 0.2517 mL 0.5034 mL 1.2585 mL
100 mM 0.0403 mL 0.2014 mL 0.4027 mL 1.0068 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Potassium succinate trihydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Potassium succinate trihydrate
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HY-W106710
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