PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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N3-Aca-Aca-OH
0 ImagesCat. No.: HY-151861CAS No.: 866363-71-5N3-Aca-Aca-OH is a bifunctional linker containing azide groups, which is a bifunctional diaminohexanoic acid (Aca dimer) and is mainly used for click chemistry coupling, ADC linker construction, and PROTAC linker design.
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Hydroxy-PEG3-I
0 ImagesCat. No.: HY-W077025CAS No.: 136399-06-9
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Benzyl 4-(3-hydroxypropyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W088806CAS No.: 99198-80-8
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(1R,3R)-3-Amino-2,2,4,4-tetramethylcyclobutan-1-ol phosphate
0 ImagesCat. No.: HY-W998338CAS No.: 1338812-52-4
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TsO-PEG3-NH-CO-OBn
0 ImagesCat. No.: HY-W583790CAS No.: 1451362-50-7
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(((7-Bromoheptyl)oxy)methyl)benzene
0 ImagesCat. No.: HY-W047157CAS No.: 94427-22-2
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tert-Butyl (6-oxohexyl)carbamate
0 ImagesCat. No.: HY-W612672CAS No.: 80860-42-0
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1-(5-Iodo-2-pyridinyl)-4-piperidinecarboxylic acid
0 ImagesCat. No.: HY-168200CAS No.: 2037137-82-71-(5-Iodo-2-pyridinyl)-4-piperidinecarboxylic acid is a PROTAC linker can be used in the synthesis of DYR684 (HY-168194).
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3-Hydroxypropyl 4-methylbenzenesulfonate
0 ImagesCat. No.: HY-W572064CAS No.: 81842-71-9Synonyms: TOS-PR-OH
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tert-Butyl 3-(azetidin-3-yl)pyrrolidine-1-carboxylate
0 ImagesCat. No.: HY-W093831CAS No.: 1314771-82-8
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PEG3-bis-NHMe
0 ImagesCat. No.: HY-W795009CAS No.: 68960-89-4
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Ethyl 5-chloropentanoate
0 ImagesCat. No.: HY-W194311CAS No.: 2323-81-1
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NH2-PEG7-C-COOH
0 ImagesCat. No.: HY-W401256CAS No.: 177580-10-8
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MS-PEG3-O-MS
0 ImagesCat. No.: HY-W151570CAS No.: 80322-82-3
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(4-Bromobutyl)boronic acid
0 ImagesCat. No.: HY-W317565CAS No.: 61632-72-2
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NH2-PEG6-C1-Boc
0 ImagesCat. No.: HY-135918CAS No.: 297162-50-6
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1,4-Bis((tetrahydrofuran-2-yl)oxy)butane
0 ImagesCat. No.: HY-W419902CAS No.: 76702-30-2
