PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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14-(Fmoc-amino)-tetradecanoic acid
0 ImagesCat. No.: HY-W591968CAS No.: 1931109-55-514-(Fmoc-amino)-tetradecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. 14-(Fmoc-amino)-tetradecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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Methyl 3-(aminomethyl)bicyclo[1.1.1]pentane-1-carboxylate hydrochloride
![Methyl 3-(aminomethyl)bicyclo[1.1.1]pentane-1-carboxylate hydrochloride](https://file.medchemexpress.com/product_pic/hy-w063706.gif "Click to View Methyl 3-(aminomethyl)bicyclo[1.1.1]pentane-1-carboxylate hydrochloride Product Detail")
0 ImagesCat. No.: HY-W063706CAS No.: 1638761-28-0
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tert-butyl 4-(2-Ethoxy-1,1-difluoro-2-oxoethyl)-5,6-dihydropyridine-1(2H)-carboxylate
0 ImagesCat. No.: HY-W001761CAS No.: 1258637-70-5
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tert-Butyl (azetidin-3-ylmethyl)(methyl)carbamate
0 ImagesCat. No.: HY-W249731CAS No.: 1053655-53-0
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1,8-Nonadiyne
0 ImagesCat. No.: HY-W540245CAS No.: 2396-65-8
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tert-Butyl (4-chlorobutyl)carbamate
0 ImagesCat. No.: HY-W101721CAS No.: 95388-79-7
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Dimethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate
![Dimethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate](https://file.medchemexpress.com/product_pic/hy-w001055.gif "Click to View Dimethyl bicyclo[1.1.1]pentane-1,3-dicarboxylate Product Detail")
0 ImagesCat. No.: HY-W001055CAS No.: 115913-32-1
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1,15-Dibromopentadecane
0 ImagesCat. No.: HY-W614239CAS No.: 81726-81-0
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4-(4-((tert-Butoxycarbonyl)amino)phenyl)butanoic acid
0 ImagesCat. No.: HY-W102026CAS No.: 105300-90-1
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6-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-hexanamine
![6-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-hexanamine](https://file.medchemexpress.com/product_pic/hy-w589432.gif "Click to View 6-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-hexanamine Product Detail")
0 ImagesCat. No.: HY-W589432CAS No.: 124883-99-4
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tert-Butyl N-[cis-3-(aminomethyl)cyclobutyl]carbamate
![tert-Butyl N-[cis-3-(aminomethyl)cyclobutyl]carbamate](https://file.medchemexpress.com/product_pic/hy-w056098.gif "Click to View tert-Butyl N-[cis-3-(aminomethyl)cyclobutyl]carbamate Product Detail")
0 ImagesCat. No.: HY-W056098CAS No.: 871014-28-7
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Mal-NH-PEG12-acid
0 ImagesCat. No.: HY-W876254CAS No.: 871133-36-7Mal-NH-PEG12-acid is a derivative of Mal-PEG12-acid (HY-140962). Mal-PEG12-acid is a PROTAC linker and belongs to the PEG class.
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Tert-butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]Nonane-7-carboxylate
![Tert-butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]Nonane-7-carboxylate](https://file.medchemexpress.com/product_pic/hy-w424240.gif "Click to View Tert-butyl 2-(2-hydroxyethyl)-7-azaspiro[3.5]Nonane-7-carboxylate Product Detail")
0 ImagesCat. No.: HY-W424240CAS No.: 1370210-93-7
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18-Mercaptooctadecanoic acid
0 ImagesCat. No.: HY-W614609CAS No.: 600730-11-8
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CbzNH-(C5-O)2-C4-Boc
0 ImagesCat. No.: HY-403544CAS No.: 2324147-95-5CbzNH-(C5-O)2-C4-Boc is a PROTAC linker. CbzNH-(C5-O)2-C4-Boc can be used for the synthesis of PROTAC CRBN-6-5-5-VHL (HY-136262).
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cis-3-[(Benzyloxy)methyl]cyclobutanol
![cis-3-[(Benzyloxy)methyl]cyclobutanol](https://file.medchemexpress.com/product_pic/hy-22345a.gif "Click to View cis-3-[(Benzyloxy)methyl]cyclobutanol Product Detail")
0 ImagesCat. No.: HY-22345ACAS No.: 172324-68-4
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Thiol-PEG5-alcohol
0 ImagesCat. No.: HY-133293CAS No.: 248582-03-8Synonyms: HS-PEG5-OH
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TBS-PEG4-COOH
0 ImagesCat. No.: HY-W614958CAS No.: 1807540-77-7
