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CRBN-6-5-5-VHL 

Cat. No.: HY-136262
Handling Instructions

CRBN-6-5-5-VHL is a potent and selective cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3.

For research use only. We do not sell to patients.

CRBN-6-5-5-VHL Chemical Structure

CRBN-6-5-5-VHL Chemical Structure

CAS No. : 2362575-45-7

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Description

CRBN-6-5-5-VHL is a potent and selective cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3[1].

IC50 & Target[1]

Cereblon

1.5 nM (DC50)

Molecular Weight

972.20

Formula

C₅₁H₆₉N₇O₁₀S

CAS No.

2362575-45-7

SMILES

O=C(N1C(CCC2=O)C(N2)=O)C(C(C1=O)=CC=C3)=C3NCCCCCCOCCCCCOCCCCC(N[[email protected]@H](C(C)(C)C)C(N(C[[email protected]@H]4O)[[email protected]@H](C4)C(NCC5=CC=C(C(SC=N6)=C6C)C=C5)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CRBN-6-5-5-VHLPROTACProteolysis-targeting chimeraVHLE3ligasesdegradationInhibitorinhibitorinhibit

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CRBN-6-5-5-VHL
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HY-136262
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