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  4. CRBN-6-5-5-VHL

CRBN-6-5-5-VHL is a potent and selective von Hippel-Lindau-based cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3.

For research use only. We do not sell to patients.

CRBN-6-5-5-VHL Chemical Structure

CRBN-6-5-5-VHL Chemical Structure

CAS No. : 2362575-45-7

Size Price Stock Quantity
5 mg USD 380 In-stock
10 mg USD 650 In-stock
25 mg USD 1350 In-stock
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100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

CRBN-6-5-5-VHL Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

CRBN-6-5-5-VHL is a potent and selective von Hippel-Lindau-based cereblon (CRBN) degrader with a DC50 value of 1.5 nM. CRBN-6-5-5-VHL has almost no effect on the degradation of the neo-substrates IKZF1 and IKZF3[1].

IC50 & Target[1]

Cereblon

1.5 nM (DC50)

Molecular Weight

972.20

Formula

C51H69N7O10S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1C(CCC2=O)C(N2)=O)C(C(C1=O)=CC=C3)=C3NCCCCCCOCCCCCOCCCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]4O)[C@@H](C4)C(NCC5=CC=C(C(SC=N6)=C6C)C=C5)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 113.33 mg/mL (116.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0286 mL 5.1430 mL 10.2859 mL
5 mM 0.2057 mL 1.0286 mL 2.0572 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.98%

COA (249 KB) HNMR (321 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0286 mL 5.1430 mL 10.2859 mL 25.7149 mL
5 mM 0.2057 mL 1.0286 mL 2.0572 mL 5.1430 mL
10 mM 0.1029 mL 0.5143 mL 1.0286 mL 2.5715 mL
15 mM 0.0686 mL 0.3429 mL 0.6857 mL 1.7143 mL
20 mM 0.0514 mL 0.2571 mL 0.5143 mL 1.2857 mL
25 mM 0.0411 mL 0.2057 mL 0.4114 mL 1.0286 mL
30 mM 0.0343 mL 0.1714 mL 0.3429 mL 0.8572 mL
40 mM 0.0257 mL 0.1286 mL 0.2571 mL 0.6429 mL
50 mM 0.0206 mL 0.1029 mL 0.2057 mL 0.5143 mL
60 mM 0.0171 mL 0.0857 mL 0.1714 mL 0.4286 mL
80 mM 0.0129 mL 0.0643 mL 0.1286 mL 0.3214 mL
100 mM 0.0103 mL 0.0514 mL 0.1029 mL 0.2571 mL
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CRBN-6-5-5-VHL Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN-6-5-5-VHL2362575-45-7PROTACsPROTACVHLE3ligasesdegradationInhibitorinhibitorinhibit

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