PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Produits associés (4095)
Produits associés (4095)
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PROTAC Linkers Isoform Comparison
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Boc-C9-Br
0 ImagesCat. No.: HY-W140827CAS No.: 1644575-06-3
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tert-Butyl 4-(2-hydroxyethoxy)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W241239CAS No.: 163210-40-0
![4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid](https://file.medchemexpress.com/product_pic/hy-w001270.gif "Click to View 4-(Methoxycarbonyl)bicyclo[2.2.2]octane-1-carboxylic acid Product Detail")
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tert-Butyl 4-(3-hydroxypropyl)tetrahydropyridine-1(2H)-carboxylate
0 ImagesCat. No.: HY-20880CAS No.: 156185-63-6
![tert-Butyl (7-azaspiro[3.5]nonan-2-yl)carbamate](https://file.medchemexpress.com/product_pic/hy-w022389.gif "Click to View tert-Butyl (7-azaspiro[3.5]nonan-2-yl)carbamate Product Detail")
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Fmoc-12-aminododecanoic acid
0 ImagesFmoc-12-aminododecanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
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cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid
0 ImagesCat. No.: HY-W041873CAS No.: 1008773-79-2
![Methyl 3-(hydroxymethyl)bicyclo[1.1.1]pentane-1-carboxylate](https://file.medchemexpress.com/product_pic/hy-w054211.gif "Click to View Methyl 3-(hydroxymethyl)bicyclo[1.1.1]pentane-1-carboxylate Product Detail")
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(9H-Fluoren-9-yl)methyl (2-hydroxyethyl)carbamate
0 ImagesSynonyms: N-Fmoc-ethanolamine
![tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-20238.gif "Click to View tert-Butyl 6-amino-2-azaspiro[3.3]heptane-2-carboxylate Product Detail")
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3-((tert-Butyldimethylsilyl)oxy)propan-1-ol
0 ImagesCat. No.: HY-W007946CAS No.: 73842-99-6
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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
![Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine](https://file.medchemexpress.com/product_pic/hy-21577.gif "Click to View Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine Product Detail")
0 ImagesTris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG/Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
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Boc-NH-PEG4-CH2COOH
0 ImagesCat. No.: HY-42640CAS No.: 876345-13-0Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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1-Boc-azetidine-3-yl-methanol
0 Images1-Boc-azetidine-3-yl-methanol is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-yl-methanol is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]-
m-PEG3-CH2CH2COOH
0 Imagesm-PEG3-CH2CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG3-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
