PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4114)
Related Products (4114)
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PROTAC Linkers Isoform Comparison
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PEG2-Dichloride
0 ImagesSynonyms: Triglycol dichloride
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2-(But-3-yn-1-yloxy)tetrahydro-2H-pyran
0 ImagesCat. No.: HY-W128289CAS No.: 40365-61-5
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Hydroxy-PEG2-acid
0 ImagesCat. No.: HY-124380CAS No.: 1334286-77-9
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4-BocNH-Bicyclo[2.2.2]octane-COOH
![4-BocNH-Bicyclo[2.2.2]octane-COOH](https://file.medchemexpress.com/product_pic/hy-w001271.gif "Click to View 4-BocNH-Bicyclo[2.2.2]octane-COOH Product Detail")
0 ImagesCat. No.: HY-W001271CAS No.: 863304-76-1
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2-(cis-4-((tert-Butoxycarbonyl)amino)cyclohexyl)acetic acid
0 ImagesCat. No.: HY-W005631CAS No.: 327156-95-6
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4-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)butanoic acid
0 ImagesCat. No.: HY-W077284CAS No.: 221124-57-8Synonyms: FMoc-N-Me-Abu(4)-OH
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Boc-C9-COOH
0 ImagesCat. No.: HY-W108995CAS No.: 1789702-17-5
![3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde](https://file.medchemexpress.com/product_pic/hy-w056267.gif "Click to View 3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde Product Detail")
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Boc-Azetidine-C2-NH2
0 ImagesCat. No.: HY-40347CAS No.: 898271-20-0
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tert-Butyl 4-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methylene)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W059361CAS No.: 1425970-61-1
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Benzyl 4-(2-hydroxyethyl)piperidine-1-carboxylate
0 ImagesCat. No.: HY-W113678CAS No.: 115909-91-6
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tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate
![tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate](https://file.medchemexpress.com/product_pic/hy-w056320.gif "Click to View tert-Butyl 6-(aminomethyl)-2-azaspiro[3.3]heptane-2-carboxylate Product Detail")
0 ImagesCat. No.: HY-W056320CAS No.: 1363380-79-3
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tert-Butyl 3-(piperazin-1-yl)azetidine-1-carboxylate
0 ImagesCat. No.: HY-42167CAS No.: 178311-48-3
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4-(2-Propynyloxy)benzaldehyde
0 ImagesCat. No.: HY-W077974CAS No.: 5651-86-5
