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Cat. No.: HY-17421A

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Tenatoprazole sodium

Name: Tenatoprazole sodium
Brand: MedChemExpress
SKU: HY-17421A
Availability: PreOrder

(Synonyms: TU-199 sodium)

Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H⁺/K⁺-ATPase with an IC₅₀ of 6.2 μM.

For research use only. We do not sell to patients.

CAS No.: 335299-59-7
Formula: C₁₆H₁₇N₄NaO₃S
Molecular Weight:368.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Tenatoprazole sodium Chemical Structure

CAS No.: 335299-59-7

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Tenatoprazole sodium (TU-199 sodium) is a proton pump inhibitor; inhibits hog gastric H⁺/K⁺-ATPase with an IC₅₀ of 6.2 μM.

IC₅₀ & Target

IC50: 6.2 μM (H⁺/K⁺-ATPase)^[1]

In Vitro

Tenatoprazole inhibits hog gastric H⁺/K⁺-ATPase activity with almost equal potency to that of omeprazole (IC₅₀=6.2 and 4.2 microM, respectively)^[1]. Tenatoprazole is a prodrug of the proton pump inhibitor class. Tenatoprazole is converted to the active sulfenamide or sulfenic acid by acid in the secretory canaliculus of the stimulated parietal cell of the stomach. This active species binds to luminally accessible cysteines of the gastric H⁺/K⁺-ATPase resulting in disulfide formation and acid secretion inhibition. Tenatoprazole binds at the catalytic subunit of the gastric acid pump with a stoichiometry of 2.6 nmol/mg of the enzyme^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tenatoprazole inhibits basal gastric acid secretion in pylorus-ligated rats in a dose-dependent manner (ED₅₀=4.2 mg/kg p.o.). In gastric fistula rats, tenatoprazole (2.5 and 5 mg/kg i.d.) also inhibits gastric acid secretion stimulated by histamine, carbachol or tetragastrin. Furthermore, tenatoprazole prevents the formation of water-immersion restraint stress-, pylorus ligation- and indomethacin-induced gastric lesions, and mepirizole-induced duodenal ulcer in rats^[1]. Maximum binding of tenatoprazole is 2.9 nmol/mg of the enzyme at 2 h after IV administration. The binding sites of tenatoprazole are in the TM5/6 region at Cys813 and Cys822. The bioavailability of tenatoprazole is two-fold greater in the (S)-tenatoprazole sodium salt hydrate form as compared to the free form in dogs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 335299-59-7
Molecular Weight 368.39
Formula C₁₆H₁₇N₄NaO₃S
SMILES

O=S(C1=NC2=CC=C(OC)N=C2[N-]1)CC3=NC=C(C)C(OC)=C3C.[Na+]
Synonyms

TU-199 sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shin JM, et al. Characterization of the inhibitory activity of tenatoprazole on the gastric H+,K+ -ATPase in vitro and in vivo. Biochem Pharmacol. 2006 Mar 14;71(6):837-49. [Content Brief]

[2]. https://www.ncbi.nlm.nih.gov/pubmed/16405921 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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