Anticancer agent 55
Anticancer agent 55 is a potent anticancer agent. Anticancer agent 55 shows anticancer activity via reducing the cell viability and cell migration in a dose-dependent manner. Anticancer agent 55 induces apoptosis. Anticancer agent 55 has the potential for the research of prostate cancer and breast cancer.
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- CAS No.: 2408800-91-7
- 화학식: C28H21Br2FN2O2
- 분자량:596.28
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MCF7 | IC50 |
1.95 μM
Compound: 3h
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Cytotoxicity against human MCF7 cells assessed as reduction cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction cell viability incubated for 48 hrs by MTS assay
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[PMID: 31901746] |
| PC-3 | IC50 |
1.18 μM
Compound: 3h
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Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human PC-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
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[PMID: 31901746] |
Anticancer agent 55 (compound 3h) (0-100 μM; 48 h) inhibits cell viability with IC50s of 1.18 μM and 1.95 μM for PC-3, MCF-7 cells, respectively[1].
Anticancer agent 55 (0, 1, 3, 10 μM; 24 h) inhibits cell migration of PC-3 cells and MCF-7 cells in a dose-dependent manner[1].
Anticancer agent 55 (0, 1, 3, 10 μM; 12, 24 h) induces apoptosis by increases the caspase-3 activity and cleaved PARP levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3, MCF-7 cells
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Concentration:0-100 µM
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Incubation Time:48 h
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Result:Significantly inhibited cell viability of PC-3, MCF-7 cells with IC50s of 1.18 µM and 1.95 µM, respectively.
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Cell Line:PC-3, MCF-7 cells
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Concentration:0, 1, 3, 10 µM
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Incubation Time:PC-3 for 12 h; MCF-7 for 24 h
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Result:Induced apoptosis by increased the caspase-3 activity in a concentration-dependent manner.
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Cell Line:PC-3, MCF-7 cells
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Concentration:0, 1, 3, 10 µM
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Incubation Time:PC-3 for 12 h; MCF-7 for 24 h
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Result:Increased cleaved PARP levels in a dose-dependent manner in PC-3 and MCF-7 cells.
Chemical Information
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CAS No. 2408800-91-7
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분자량 596.28
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화학식 C28H21Br2FN2O2
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SMILES
O=C(C1=CC=CC=C1)C[N+]2=CC3=CC=CN3[C@@H](C2C4=CC=C(C=C4)Br)C(C5=CC=C(C=C5)F)=O.[Br-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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