country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-156468

Copy Link Print Information

Antioxidant agent-17

Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC₅₀ of 9.06 nM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₀H₁₅FN₂O
Molecular Weight:318.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Antioxidant agent-17 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Antioxidant agent-17 (compound 59) is a potent inhibitor of superoxide anion generation activity, with an IC₅₀ of 9.06 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	IC₅₀	>10000 nM Compound: 59	Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate incubated for 5 mins Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in elastase release using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate incubated for 5 mins	[PMID: 37918036]
Neutrophil	IC₅₀	9.06 nM Compound: 59	Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion generation preincubated with compound for 2 mins prior to CB induction for 3 mins followed by fMLF addition by spectrophotometric analysis Inhibition of fMLF/CB-induced human Neutrophil activation assessed as reduction in superoxide anion generation preincubated with compound for 2 mins prior to CB induction for 3 mins followed by fMLF addition by spectrophotometric analysis	[PMID: 37918036]

In Vivo

The half-life of Antioxidant agent-17 (compound 59) is approximately 79 min when using intravenous bolus administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 318.34
Formel C₂₀H₁₅FN₂O
SMILES

FC1=CC=CC=C1CN2N=C(C3=CC=CO3)C=C2C4=CC=CC=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yu KH, et al. Design and synthesis of pyrazole derivatives against neutrophilic inflammation. Eur J Med Chem. 2023 Oct 26;262:115874. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen