UBE4B - ubiquitination factor E4B Gene

Also Known as E4; UFD2; HDNB1; UBOX3; UFD2A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10277

About UBE4B

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:10,032,958-10,181,239 (from NCBI)

This gene has 10 transcripts (splice variants), 215 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 12.1), skin (RPKM 10.9) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UBE4B Products (3)

mRNA Protein Name
NM_001105562.3 NP_001099032.1 ubiquitin conjugation factor E4 B isoform 1
NM_001410744.1 NP_001397673.1 ubiquitin conjugation factor E4 B isoform 3
NM_006048.5 NP_006039.2 ubiquitin conjugation factor E4 B isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
20696396 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in granzyme-mediated apoptotic signaling pathway IDA
IDA: Inferred from direct assay
11802788 GOA
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23509263 GOA
involved in response to UV IDA
IDA: Inferred from direct assay
11802788 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE4B Protein Structure

Ufd2P_core

Ufd2P_core: Ubiquitin elongating factor core (591 - 1213)

U-box

U-box: U-box domain (1228 - 1299)

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  • 1302 a.a.
Protein Preferred Names Protein Names

ubiquitin conjugation factor E4 B

  • RING-type E3 ubiquitin transferase E4 B

UBE4B Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P83563 Ubiquitin Conjugation Factor E4 B Antibody (YA3308) WB, ICC/IF Human, Rat
HY-P83563A Ubiquitin Conjugation Factor E4 B Antibody (YA3308)(PBS only) WB, ICC/IF Human, Rat

Related Diseases

Diseases Alias
Chromosome 1p36 Deletion Syndrome

  • 1p36 Deletion Syndrome

  • Deletion 1p36

  • Monosomy 1p36

  • Subtelomeric 1p36 Deletion

  • Monosomy 1p36 Syndrome

  • Distal Monosomy 1p36

  • Del(1)(P36)

  • Deletion 1pter

  • Monosomy 1pter
Neuroblastoma 1

  • Neuroblastoma, Susceptibility To, 1

  • NBLST1

  • Neuroblastoma, Susceptibility To, Type 1
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Complement Component 7 Deficiency

  • C7 Deficiency

  • C7D
Wallerian Degeneration

  • Wallerian Degeneration Of The Pyramidal Tract
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

  • Ibmpfd

  • Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia

  • Pagetoid Amyotrophic Lateral Sclerosis

  • Pagetoid Neuroskeletal Syndrome

  • Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia

  • Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia

  • Multisystem Proteinopathy

  • Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone

  • Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia

  • Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement

  • Lower Motor Neuron Degeneration With Paget-Like Bone Disease

  • Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone

  • Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS15372 UBE4B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21073 Ube4b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27590 Ube4b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris UBE4B VGNC VGNC:48073
Bos taurus UBE4B VGNC VGNC:36604
Rattus norvegicus UBE4B RGD RGD:1304738
Mus musculus UBE4B MGD MGI:1927086
Felis catus UBE4B VGNC VGNC:66772
Macaca mulatta UBE4B VGNC VGNC:78700
Others UBE4B NCBI