GBP3 - guanylate binding protein 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2635

About GBP3

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,006,680-89,022,866 (from NCBI)

This gene has 11 transcripts (splice variants), 42 orthologues and 10 paralogues. Broad expression in duodenum (RPKM 41.6), small intestine (RPKM 35.5) and 23 other tissues.

Summary

This gene encodes a member of the guanylate-binding protein (GBP) family. GBPs specifically bind guanine nucleotides (GMP, GDP, and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins. The encoded protein interacts with a member of the germinal center kinase family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2017]

GBP3 Products (4)

mRNA	Protein	Name
NM_001319179.2	NP_001306108.1	guanylate-binding protein 3 isoform 2
NM_001319180.2	NP_001306109.1	guanylate-binding protein 3 isoform 3
NM_001319181.2	NP_001306110.1	guanylate-binding protein 3 isoform 4
NM_018284.3	NP_060754.2	guanylate-binding protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21151871	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12387898	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	21151871	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	17266443	GOA
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	17266443	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17266443	GOA
located in cytosol	IDA IDA: Inferred from direct assay	21151871	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GBP3 Protein Structure

GBP

GBP_C

0
100
200
300
400
500
595 a.a.

Protein Preferred Names	Protein Names
guanylate-binding protein 3	GTP-binding protein 3

GBP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	GBP3	Q9H0R5	MAP4K4	Homo sapiens	O95819	Pull Down	12387898
Intra	GBP3	Q9H0R5	MAP4K4	Homo sapiens	O95819	Y2H	12387898
Intra	GBP3	Q9H0R5	S100A10	Homo sapiens	P60903	Crosslink	30021884
Intra	GBP3	Q9H0R5	tktA	Francisella tularensis subsp. tularensis	Q5NF74	Y2H Pooling	20711500
Intra	GBP3	Q9H0R5	GBP2	Homo sapiens	P32456	Anti Tag CoIP	33961781
Intra	GBP3	Q9H0R5	ACTL6B	Homo sapiens	O94805	Anti Tag CoIP	33961781
Intra	GBP3	Q9H0R5	DECR2	Homo sapiens	Q9NUI1	Anti Tag CoIP	33961781
Intra	GBP3	Q9H0R5	CASP6	Homo sapiens	P55212	Anti Tag CoIP	33961781
Intra	GBP3	Q9H0R5	GBP3	Homo sapiens	Q9H0R5	Y2H	21151871
Intra	GBP3	Q9H0R5	GBP3	Homo sapiens	Q9H0R5	Anti Tag CoIP	21151871

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Orofacial Cleft 8	OFC8 Cleft Lip With Or Without Cleft Palate, Nonsyndromic, 8 Non-Syndromic Cleft Lip/Palate 8 Non-Syndromic Cleft Lip With Or Without Cleft Palate 8 Orofacial Cleft, Type 8

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01157	ATL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05309	GBP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22180	Gbp3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28702	Gbp3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GBP3	MGD	MGI:95666
Rattus norvegicus	GBP3	RGD	RGD:1597766
Others	GBP3	NCBI